Eliasova Petra, Kolostova Katarina, Kobierzycki Christopher, Bobek Vladimir
Department of Tumor Biology, Third Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Surgery, Third Faculty of Medicine, Charles University and University Hospital, Kralovske Vinohrady, Prague, Czech Republic.
Folia Histochem Cytobiol. 2013;51(4):265-77. doi: 10.5603/FHC.2013.0037.
Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are responsible for the development of metastatic disease, and may also hold the key to determining tailored therapies of advanced cancer disease. Our review summarizes the prognostic significance of the detection of CTCs and DTCs in various gastrointestinal cancers with an overview of their possible use as prognostic biomarkers. This could be used inthe future as a starting point for new clinical trials focusing on the predictive potential of circulating and disseminated tumor cells.
循环肿瘤细胞（CTCs）和播散肿瘤细胞（DTCs）是转移性疾病发生的原因，也可能是确定晚期癌症个性化治疗方法的关键。我们的综述总结了检测CTCs和DTCs在各种胃肠道癌症中的预后意义，并概述了它们作为预后生物标志物的可能用途。这在未来可作为新临床试验的起点，这些试验聚焦于循环肿瘤细胞和播散肿瘤细胞的预测潜力。
