胃肠道肿瘤学中的播散和循环肿瘤细胞。

Disseminated and circulating tumor cells in gastrointestinal oncology.

机构信息

Department of Medical Oncology, Institut Curie, Paris, France.

出版信息

Crit Rev Oncol Hematol. 2012 May;82(2):103-15. doi: 10.1016/j.critrevonc.2011.05.008. Epub 2011 Jun 15.

DOI:10.1016/j.critrevonc.2011.05.008

Abstract

Circulating (CTCs) and disseminated tumor cells (DTCs) are two different steps in the metastatic process. Several recent techniques have allowed detection of these cells in patients, and have generated many results using different isolation techniques in small cohorts. Herein, we review the detection results and their clinical consequence in esophageal, gastric, pancreatic, colorectal, and liver carcinomas, and discuss their possible applications as new biomarkers.

摘要

循环肿瘤细胞 (CTCs) 和播散肿瘤细胞 (DTCs) 是转移过程中的两个不同步骤。最近的一些技术已经允许在患者中检测到这些细胞，并使用不同的分离技术在小队列中产生了许多结果。在此，我们回顾了食管癌、胃癌、胰腺癌、结直肠癌和肝癌中这些细胞的检测结果及其临床意义，并讨论了它们作为新的生物标志物的可能应用。