Jiang Kai, Zhang Wen-zhi, Liu Yang, Su Ming, Zhao Xiang-qian, Dong Jia-hong, Huang Zhi-qiang
Institute & Hospital of Hepatobiliary Surgery, Key Laboratory of Digital Hepatobiliary Surgery of Chinese PLA, Chinese PLA Medical School, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China,
Cell Biochem Biophys. 2014 Jul;69(3):605-17. doi: 10.1007/s12013-014-9840-8.
Radiofrequency ablation (RFA) is an effective, minimally invasive treatment option for unresectable hepatocellular carcinomas (HCCs) located in high-risk areas or for patients with poor hepatic functional reserve. However, for tumors adjacent to major bile ducts and hepatic blood vessels, complete ablation is difficult to achieve for fear of causing a postoperative bile leak, bilioma or bile duct stenosis. Therefore, RFA is often combined with multiple alcohol injections to eliminate residual tumor tissues in adjacent bile duct or blood vessels; however, the injections directly affect the efficacy and prognosis of RFA. This study reports three successful "one-off" cases of complete ablation of HCCs adjacent to major bile ducts and blood vessels in neighboring hepatic segments or hepatic lobes, highlighting both the efficacy and safety of RFA for HCC tumors in these high-risk locations.
射频消融（RFA）是一种有效的微创治疗选择，适用于位于高危区域的不可切除肝细胞癌（HCC）或肝功能储备较差的患者。然而，对于邻近主要胆管和肝血管的肿瘤，由于担心术后胆漏、胆汁瘤或胆管狭窄，难以实现完全消融。因此，RFA常与多次酒精注射联合使用，以消除邻近胆管或血管中的残留肿瘤组织；然而，这些注射会直接影响RFA的疗效和预后。本研究报告了3例成功的“一次性”完全消融邻近主要胆管和肝血管的肝段或肝叶HCC的病例，突出了RFA对这些高危部位HCC肿瘤的疗效和安全性。
