Ashikbayeva Zhannat, Aitkulov Arman, Atabaev Timur Sh, Blanc Wilfried, Inglezakis Vassilis J, Tosi Daniele
School of Engineering and Digital Sciences, Nazarbayev University, 53 Kabanbay Batyr Ave., Nur-Sultan 010000, Kazakhstan.
Department of Information Engineering, University of Padova, Via Gardenigo 6/A, 35131 Padova, Italy.
Nanomaterials (Basel). 2022 Jan 27;12(3):426. doi: 10.3390/nano12030426.
Thermal ablation therapy is known as an advantageous alternative to surgery allowing the treatment of multiple tumors located in hard-to-reach locations or treating patients with medical conditions that are not compatible with surgery. Appropriate heat propagation and precise control over the heat propagation is considered a weak point of thermal ablation therapy. In this work, silver nanoparticles (AgNPs) are used to improve the heat propagation properties during the thermal ablation procedure. Green-synthesized silver nanoparticles offer several attractive features, such as excellent thermal conductivity, biocompatibility, and antimicrobial activity. A distributed multiplexed fiber optic sensing system is used to monitor precisely the temperature change during nanoparticle-assisted radiofrequency ablation. An array of six MgO-based nanoparticles doped optical fibers spliced to single-mode fibers allowed us to obtain the two-dimensional thermal maps in a real time employing optical backscattering reflectometry at 2 mm resolution and 120 sensing points. The silver nanoparticles at 5, 10, and 20 mg/mL were employed to investigate their heating effects at several positions on the tissue regarding the active electrode. In addition, the pristine tissue and tissue treated with agarose solution were also tested for reference purposes. The results demonstrated that silver nanoparticles could increase the temperature during thermal therapies by propagating the heat. The highest temperature increase was obtained for 5 mg/mL silver nanoparticles introduced to the area close to the electrode with a 102% increase of the ablated area compared to the pristine tissue.
热消融疗法是一种优于手术的治疗方法，可用于治疗位于难以触及部位的多个肿瘤，或治疗因身体状况不适合手术的患者。适当的热传播以及对热传播的精确控制被认为是热消融疗法的一个弱点。在这项工作中，银纳米颗粒（AgNPs）被用于改善热消融过程中的热传播特性。绿色合成的银纳米颗粒具有几个吸引人的特性，如优异的热导率、生物相容性和抗菌活性。一个分布式复用光纤传感系统被用于精确监测纳米颗粒辅助射频消融过程中的温度变化。一系列六个掺有MgO基纳米颗粒的光纤与单模光纤熔接，使我们能够利用光学背向散射反射法以2毫米的分辨率和120个传感点实时获取二维热图。使用5、10和20毫克/毫升的银纳米颗粒来研究它们在组织上相对于活性电极的几个位置的加热效果。此外，还对原始组织和用琼脂糖溶液处理过的组织进行了测试以供参考。结果表明，银纳米颗粒可以通过传播热量来提高热疗过程中的温度。对于引入到靠近电极区域的5毫克/毫升银纳米颗粒，温度升高最高，与原始组织相比，消融面积增加了102%。
