Hillman Richard J, Garland Suzanne M, Gunathilake Manoji P W, Stevens Matthew, Kumaradevan Nirmala, Lemech Charlotte, Ward Robyn L, Meagher Alan, McHugh Leo, Jin Fengyi, Carroll Susan, Goldstein David, Grulich Andrew E, Tabrizi Sepehr N
Western Sydney Sexual Health Centre, University of Sydney, Westmead Hospital, Sydney, Australia.
Int J Cancer. 2014 Aug 15;135(4):996-1001. doi: 10.1002/ijc.28730. Epub 2014 Feb 4.
Human papillomavirus (HPV) causes most cases of anal cancers. In this study, we analyzed biopsy material from 112 patients with anal cancers in Australia for the presence of HPV DNA by the INNO LiPA HPV genotyping assay. There were 82% (92) males and 18% (20) females. The mean age at diagnosis was significantly (p = 0.006) younger for males (52.5 years) than females (66 years). HIV-infected males were diagnosed at a much earlier mean age (48.2 years) than HIV negative (56.3 years) males (p = 0.05). HPV DNA was detected in 96.4% (108) of cases. HPV type 16 was the commonest, at 75% (81) of samples and being the sole genotype detected in 61% (66). Overall, 79% (85) of cases had at least one genotype targeted by the bivalent HPV (bHPV) vaccine, 90% (97) by the quadrivalent HPV (qHPV) vaccine and 96% (104) by the nonavalent HPV (nHPV) vaccine. The qHPV vaccine, which is now offered to all secondary school students in Australia, may prevent anal cancers in Australia. However, given the mean age of onset of this condition, the vaccine is unlikely to have a significant impact for several decades. Further research is necessary to prove additional protective effects of the nHPV vaccine.
人乳头瘤病毒（HPV）引发了大多数肛管癌病例。在本研究中，我们通过INNO LiPA HPV基因分型检测法，分析了澳大利亚112例肛管癌患者活检材料中HPV DNA的存在情况。其中男性占82%（92例），女性占18%（20例）。男性的确诊平均年龄（52.5岁）显著低于女性（66岁）（p = 0.006）。感染HIV的男性确诊平均年龄（48.2岁）比未感染HIV的男性（56.3岁）要早得多（p = 0.05）。96.4%（108例）的病例检测到HPV DNA。HPV 16型最为常见，占样本的75%（81例），且在61%（66例）中为唯一检测到的基因型。总体而言，79%（85例）的病例至少有一种基因型可被二价HPV（bHPV）疫苗靶向，90%（97例）可被四价HPV（qHPV）疫苗靶向，96%（104例）可被九价HPV（nHPV）疫苗靶向。目前澳大利亚向所有中学生提供的qHPV疫苗，可能会预防该国的肛管癌。然而，鉴于这种疾病的发病平均年龄，该疫苗在几十年内不太可能产生显著影响。有必要进行进一步研究，以证实nHPV疫苗的额外保护作用。
