National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.
London School of Hygiene and Tropical Medicine, London, UK.
Int J Infect Dis. 2021 Nov;112:136-143. doi: 10.1016/j.ijid.2021.09.016. Epub 2021 Sep 10.
Men who have sex with men (MSM) are at risk of human papillomavirus (HPV)-related cancers, while published data are scarce. This study determined HPV prevalence and risk factors in MSM in Vietnam to inform HPV prevention strategies in this key population.
A cross-sectional study of 799 MSM aged 16-50 years was conducted in Vietnam in 2017-2018. Information was collected on risk behaviours, and knowledge of HPV and anal cancer; rectal swabs were taken to detect anal HPV infection. An in-house polymerase chain reaction and Genoflow HPV array test kit were used for HPV detection and genotyping.
The median age of the study participants was 25 years (range 18-52). Overall prevalence of any HPV and HPV16/18 infection was 32.3% and 11.0%, respectively. A higher prevalence of high-risk HPV infection to all 14 types tested was found in Ho Chi Minh City (30.9%) than in Hanoi (18.4%). High-risk HPV infection was associated with inconsistent condom use and history of engaging in sex under the influence of drugs (adjusted odds ratio (aOR), 2.27; 95% CI, 1.48-10.67), as well as having multiple sexual partners (aOR, 1.01; 95% CI, 1.00-1.02).
High-risk anal HPV infections in Vietnamese MSM were significantly associated with risky sexual behaviours. A targeted HPV vaccination strategy would have substantial benefit for MSM in Vietnam.
男男性行为者（MSM）存在人乳头瘤病毒（HPV）相关癌症风险，而相关的已发表数据却很少。本研究旨在确定越南 MSM 中的 HPV 流行情况和危险因素，以为该重点人群提供 HPV 预防策略。
2017 年至 2018 年在越南对 799 名年龄在 16-50 岁的 MSM 进行了横断面研究。收集了风险行为、HPV 和肛门癌相关知识的信息；采集直肠拭子以检测肛门 HPV 感染。使用内部聚合酶链反应和 Genoflow HPV 基因芯片试剂盒进行 HPV 检测和基因分型。
研究参与者的中位年龄为 25 岁（范围 18-52 岁）。总的 HPV 和 HPV16/18 感染率分别为 32.3%和 11.0%。与首都河内（18.4%）相比，胡志明市（30.9%）的高危 HPV 感染率更高。与所有 14 种测试类型相比，高危 HPV 感染与 condom 使用不一致和有过吸毒后性行为史（调整后的优势比（aOR），2.27；95%可信区间（CI），1.48-10.67）以及有多个性伴侣（aOR，1.01；95%CI，1.00-1.02）有关。
越南 MSM 中的高危肛门 HPV 感染与危险性行为显著相关。针对 MSM 的 HPV 疫苗接种策略将对越南的 MSM 产生重大影响。
