睾丸生殖细胞肿瘤患者血清中表位定义标志物的概况。
Profiles of epitope-defined markers in sera from patients with testicular germ cell tumors.
作者信息
Yamamoto H, Rudén U, Esposti P, Hirano K, Stigbrand T, Andersson L, Hisazumi H, Wahren B
机构信息
Department of Virology, National Bacteriological Laboratory, Stockholm, Sweden.
出版信息
Urol Res. 1988;16(1):31-6. doi: 10.1007/BF00264625.
Epitope-defined tumor markers of AFP (FA), HCG (PM), PLAP (H7) and CEA (D/AH) were determined by monoclonal antibodies in sera of patients with germ cell tumors of the testis. Characteristic profiles of PLAP (H7) were seen in localized and metastatic seminoma and in sera of patients with mixed tumors with seminoma components. PLAP (H7) levels started to rise 10 months before clinical detection of recurrence in one case. Persisting elevated levels of PLAP (H7) in several cases were indicative of metastatic seminoma. PLAP (H7) occurred rarely in sera of patients with metastasing non-seminomatous tumors. AFP (FA) detected in seminoma sera led to identification of non-seminomatous disease in one case. High AFP (FA) alone occurred in yolk sac tumors, HCG (PM) with AFP (FA) or PLAP (H7) in patients where the tumors had components of teratoma and/or embryonal carcinoma, moderately elevated levels of AFP (FA) and sometimes also HCG (PM) occurred.
采用单克隆抗体测定睾丸生殖细胞瘤患者血清中由表位定义的甲胎蛋白（FA）、人绒毛膜促性腺激素（PM）、胎盘碱性磷酸酶（H7）和癌胚抗原（D/AH）等肿瘤标志物。在局限性和转移性精原细胞瘤以及含有精原细胞瘤成分的混合性肿瘤患者血清中观察到胎盘碱性磷酸酶（H7）的特征性谱。在1例病例中，胎盘碱性磷酸酶（H7）水平在临床检测到复发前10个月开始升高。在几例病例中，胎盘碱性磷酸酶（H7）持续升高表明为转移性精原细胞瘤。胎盘碱性磷酸酶（H7）在转移性非精原细胞瘤患者血清中很少出现。在1例精原细胞瘤血清中检测到的甲胎蛋白（FA）导致发现了非精原细胞瘤疾病。单独的高甲胎蛋白（FA）出现在卵黄囊瘤中，人绒毛膜促性腺激素（PM）与甲胎蛋白（FA）或胎盘碱性磷酸酶（H7）同时出现在肿瘤含有畸胎瘤和/或胚胎癌成分的患者中，甲胎蛋白（FA）水平中度升高，有时人绒毛膜促性腺激素（PM）水平也会升高。
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