Wahren B, Holmgren P A, Stigbrand T
Int J Cancer. 1979 Dec 15;24(6):749-53. doi: 10.1002/ijc.2910240608.
Indirect immunofluorescence and radioimmunoassay with specific rabbit antisera demonstrated the occurrence of alphafetoprotein (AFP), carcinoembryonic antigen (CEA) and placental alkaline phosphatase (PLAP) in primary testicular tumor cells. Embryonal carcinomas had AFP- and CEA-containing cells, sometimes PLAP. PLAP and sometimes CEA were found in seminoma cells. Sera from patients with advanced non-seminomatous tumors could contain any of these antigens or any combination of them. Sera from patients with seminomas had raised PLAP or CEA. PLAP appears to be a new marker for seminoma.
用特异性兔抗血清进行的间接免疫荧光和放射免疫测定表明，原发性睾丸肿瘤细胞中存在甲胎蛋白（AFP）、癌胚抗原（CEA）和胎盘碱性磷酸酶（PLAP）。胚胎癌含有含AFP和CEA的细胞，有时还含有PLAP。精原细胞瘤细胞中发现了PLAP，有时还发现了CEA。晚期非精原细胞瘤患者的血清可能含有这些抗原中的任何一种或它们的任何组合。精原细胞瘤患者的血清中PLAP或CEA升高。PLAP似乎是精原细胞瘤的一种新标志物。
