Agrawal A, Singh L M, Sagar P
Department of Biochemistry, Central Drug Research Institute, Lucknow, India.
Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Oct;266(3-4):575-9. doi: 10.1016/s0176-6724(87)80240-7.
The action of emetine on the incorporation of (14C)1-DL-valine and (14C)-8-adenine in TCA insoluble fraction of axenic Entamoeba histolytica was investigated. These compounds were almost exclusively incorporated in the 'protein' and 'RNA' fractions, respectively. Incorporation of the purine showed a significantly higher sensitivity to emetine. While the percentage inhibition of valine incorporation by emetine decreased with increasing pH, the susceptibility of adenine incorporation was greater in the alkaline range.
