Baxendale Sallie, McGrath Katherine, Thompson Pamela J
a NIHR University College London Hospitals Biomedical Research Centre , Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology , London , UK.
J Clin Exp Neuropsychol. 2014;36(2):137-43. doi: 10.1080/13803395.2013.870535. Epub 2014 Feb 5.
We examined Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) General Ability Index (GAI) and Full Scale Intelligence Quotient (FSIQ) discrepancies in 100 epilepsy patients; 44% had a significant GAI > FSIQ discrepancy. GAI-FSIQ discrepancies were correlated with the number of antiepileptic drugs taken and duration of epilepsy. Individual antiepileptic drugs differentially interfere with the expression of underlying intellectual ability in this group. FSIQ may significantly underestimate levels of general intellectual ability in people with epilepsy. Inaccurate representations of FSIQ due to selective impairments in working memory and reduced processing speed obscure the contextual interpretation of performance on other neuropsychological tests, and subtle localizing and lateralizing signs may be missed as a result.
我们研究了100例癫痫患者的韦氏成人智力量表第四版（WAIS-IV）一般能力指数（GAI）与全量表智商（FSIQ）的差异；44%的患者存在显著的GAI>FSIQ差异。GAI-FSIQ差异与服用抗癫痫药物的数量及癫痫病程相关。在该群体中，个别抗癫痫药物对潜在智力能力的表达有不同程度的干扰。FSIQ可能会显著低估癫痫患者的一般智力水平。由于工作记忆的选择性损伤和处理速度减慢导致FSIQ的不准确表现，会模糊对其他神经心理学测试表现的背景解读，结果可能会遗漏细微的定位和定侧体征。
