生物标志物作为蛛网膜下腔出血的预后预测指标——系统评价。
Biomarkers as outcome predictors in subarachnoid hemorrhage--a systematic review.
机构信息
Department of Anesthesiology, Division of Critical Care Medicine .
出版信息
Biomarkers. 2014 Mar;19(2):95-108. doi: 10.3109/1354750X.2014.881418. Epub 2014 Feb 5.
Abstract
CONTEXT
Subarachnoid hemorrhage (SAH) has a high fatality rate and many suffer from delayed neurological deficits. Biomarkers may aid in the identification of high-risk patients, guide treatment/management and improve outcome.
OBJECTIVE
The aim of this review was to summarize biomarkers of SAH associated with outcome.
METHODS
An electronic database query was completed, including an additional review of reference lists to include all potential human studies.
RESULTS
A total of 298 articles were identified; 112 were reviewed; 55 studies were included.
CONCLUSION
This review details biomarkers of SAH that correlate with outcome. It provides the basis for research investigating their possible translation into the management of SAH patients.
摘要
背景
蛛网膜下腔出血 (SAH) 死亡率高，许多患者存在迟发性神经功能缺损。生物标志物有助于识别高危患者，指导治疗/管理并改善预后。
目的
本综述旨在总结与结局相关的蛛网膜下腔出血生物标志物。
方法
完成了电子数据库检索，并额外查阅了参考文献以纳入所有潜在的人类研究。
结果
共确定了 298 篇文章，其中 112 篇进行了综述，有 55 项研究被纳入。
结论
本综述详细介绍了与结局相关的蛛网膜下腔出血生物标志物，为研究它们在蛛网膜下腔出血患者管理中的可能转化提供了依据。
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