Liew Zeyan, Wang Anthony, Bronstein Jeff, Ritz Beate
a Department of Epidemiology, Fielding School of Public Health , University of California at Los Angeles , Los Angeles , California , USA.
Arch Environ Occup Health. 2014;69(4):241-51. doi: 10.1080/19338244.2013.778808.
Studies that report an association between Parkinson's disease (PD) and occupational pesticide exposure often use self-reported exposure and none adjust for concomitant ambient pesticide exposure. For a population-based case-control study of PD conducted in California's heavily agricultural region, the authors developed a comprehensive job exposure matrix (JEM) to assess occupational exposure to pesticides. Relying on 357 incident cases and 750 population controls enrolled between 2001 and 2011, the authors estimated more than a 2-fold risk increase for PD among men classified as highly occupationally exposed. The authors also observed an exposure-response pattern and farming tasks with direct and intense pesticide exposures such as spraying and handling of pesticides resulted in greater risks than indirect bystander exposures. Results did not change after adjustment for ambient pesticide exposure. The authors provide further evidence that occupational pesticide exposure increases the risk of PD.
报告帕金森病（PD）与职业性接触农药之间存在关联的研究，通常采用自我报告的接触情况，且均未对同时存在的环境农药接触进行校正。对于在加利福尼亚州农业高度发达地区开展的一项基于人群的PD病例对照研究，作者制定了一个全面的工作接触矩阵（JEM）来评估职业性农药接触情况。作者依据2001年至2011年期间纳入的357例新发病例和750名对照人群，估计在被归类为职业接触程度高的男性中，患PD的风险增加了两倍多。作者还观察到一种接触-反应模式，诸如喷洒和处理农药等直接且高强度接触农药的农事任务，比间接的旁观者接触导致的风险更大。在校正环境农药接触情况后，结果并未改变。作者提供了进一步的证据表明职业性农药接触会增加患PD的风险。
