加利福尼亚州圣华金河谷的拉丁裔女性中的农业暴露与乳腺癌。
Agricultural Exposures and Breast Cancer Among Latina in the San Joaquin Valley of California.
机构信息
University of California, San Francisco, Fresno Medical Education and Research Program, Fresno, California (Dr Mills and Ms Shah); University of California, San Francisco, Division of Transplant Surgery, Fresno, California (Ms Dodge); and Department of Biology, California State University, Fresno, California (Dr Bush and Ms Thompson).
出版信息
J Occup Environ Med. 2019 Jul;61(7):552-558. doi: 10.1097/JOM.0000000000001598.
OBJECTIVE
The aim of this study was to assess the role of agricultural work, pesticide exposure, and age at first farm labor exposure in breast cancer (BC) risk among Hispanic women in Central California.
METHODS
A BC case control study was conducted. Latina BC cases were identified through the California Cancer Registry and controls were recruited. Both cases and controls completed a detailed questionnaire. Pesticide exposure data were obtained by linking the crops, work locations, and dates worked in specific farm jobs with the California Department of Pesticide Regulation (DPR) Pesticide Use Reports (PUR).
RESULTS
Chemicals associated with BC risk included organophosphates, organochlorines, and a phthalimide, Captan. Age at first work in farm labor was younger in cases than controls (P = 0.03).
CONCLUSIONS
Agricultural work may be associated with the increased BC risk in female Hispanic farm workers.
目的
本研究旨在评估农业工作、农药暴露和首次农场劳动暴露年龄在加利福尼亚州中部西班牙裔妇女乳腺癌（BC）风险中的作用。
方法
进行了一项 BC 病例对照研究。通过加利福尼亚癌症登记处确定拉丁裔 BC 病例，招募对照。病例和对照均完成了详细的问卷。通过将作物、工作地点和特定农场工作的工作日期与加利福尼亚农药监管部门（DPR）的农药使用报告（PUR）联系起来，获得农药暴露数据。
结果
与 BC 风险相关的化学物质包括有机磷、有机氯和邻苯二甲酰亚胺，captan。病例首次从事农场劳动的年龄比对照组小（P=0.03）。
结论
农业工作可能与女性西班牙裔农场工人乳腺癌风险增加有关。
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