Qiu Ya, Liu Hua, Qing Yufeng, Yang Min, Tan Xiaoyao, Zhao Mingcai, Lin Monica, Zhou Jingguo
Institute of Rheumatology and Immunology, Affiliated Hospital of North Sichuan Medical College , Nanchong, Sichuan , P. R. China.
Mod Rheumatol. 2014 Sep;24(5):829-34. doi: 10.3109/14397595.2013.875639. Epub 2014 Feb 5.
Individual genetic association studies examining the relationship between the ABCG2 gene polymorphisms and gout have yielded inconsistent results. This study aims to evaluate the association between the ABCG2 gene variants and gout using meta-analysis.
Relevant studies were identified by searching databases extensively. The odds ratio (OR) was calculated using a random-effect or fixed-effect model. A Q statistic was used to evaluate homogeneity, and Egger's test and funnel plot were used to assess publication bias. Subgroup analyses on ethnicities and sex were also performed.
A total of 7 studies, including 2185 gout patients and 8028 controls from 5 countries or regions, were included and identified for the current meta-analysis. It was found that the A allele or AA genotype of the ABCG2 Q141K polymorphism (rs2231142) had an increased risk of gout in the general population (A allele, p < 0.00001 and AA genotype, p < 0.00001, respectively). On the contrary, CC homozygote played a protective role against the risk of gout (p < 0.00001). Similar results were found in subgroup analyses. However, there was a significant heterogeneity among studies.
Existing evidence indicates that the Q141K polymorphism (rs2231142, the A allele and AA genotype) is associated with an increased risk of gout.
个体基因关联研究探讨ABCG2基因多态性与痛风之间的关系，结果并不一致。本研究旨在通过荟萃分析评估ABCG2基因变异与痛风之间的关联。
通过广泛检索数据库来确定相关研究。采用随机效应或固定效应模型计算比值比（OR）。使用Q统计量评估同质性，采用Egger检验和漏斗图评估发表偏倚。还对种族和性别进行了亚组分析。
本荟萃分析共纳入并确定了7项研究，包括来自5个国家或地区的2185例痛风患者和8028例对照。结果发现，ABCG2 Q141K多态性（rs2231142）的A等位基因或AA基因型在普通人群中患痛风的风险增加（A等位基因，p < 0.00001；AA基因型，p < 0.00001）。相反，CC纯合子对痛风风险具有保护作用（p < 0.00001）。亚组分析也发现了类似结果。然而，各研究之间存在显著异质性。
现有证据表明，Q141K多态性（rs2231142，A等位基因和AA基因型）与痛风风险增加有关。
