Wu Lei, He Yao, Zhang Di
Department of Epidemiology, Institute of Geriatrics; Beijing Key Laboratory of Research on Aging and Related Diseases.
Department of Epidemiology, Institute of Geriatrics; Beijing Key Laboratory of Research on Aging and Related Diseases; State Key Laboratory of Kidney Disease, General Hospital of Chinese People's Liberation Army, Beijing 100853, China; Email:
Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Nov;36(11):1291-6.
To systematically evaluate the association between single nucleotide polymorphism of rs2231142 genetic susceptibility and gout in East Asian population.
The literature retrieval was conducted by using English databases (Medline, EMbase), Chinese databases (CNKI, Vip, Wanfang, SinaMed) and others to collect the published papers on the association between single nucleotide polymorphism of rs2231142 genetic susceptibility and gout by the end of December 2014. Meta-analysis was performed with software Stata 12.0.
Nine studies were included. There were significant associations between increased risk of gout and single nucleotide polymorphism of rs2231142, the combined OR was 2.04 (95%CI: 1.82-2.28) for A allele and C allele, 1.97 (95%CI: 1.57-2.48) for CA and CC, 3.71 (95%CI: 3.07-4.47) for AA and CC. Sex and region specific subgroup analysis showed less heterogeneity.
There is significant association between gout and single nucleotide polymorphism of rs2231142 in East Asian population, and A allele is a high risk gene for gout.
系统评价东亚人群中rs2231142基因易感性单核苷酸多态性与痛风的关联。
通过检索英文数据库（Medline、EMbase）、中文数据库（CNKI、维普、万方、中国生物医学文献数据库）及其他数据库，收集截至2014年12月发表的关于rs2231142基因易感性单核苷酸多态性与痛风关联的论文。采用Stata 12.0软件进行Meta分析。
纳入9项研究。痛风风险增加与rs2231142单核苷酸多态性之间存在显著关联，A等位基因与C等位基因的合并OR为2.04（95%CI：1.82 - 2.28），CA与CC的合并OR为1.97（95%CI：1.57 - 2.48），AA与CC的合并OR为3.71（95%CI：3.07 - 4.47）。性别和地区特异性亚组分析显示异质性较小。
东亚人群中痛风与rs2231142单核苷酸多态性之间存在显著关联，A等位基因是痛风的高风险基因。
