Brunia C H, Damen E J
Dept. of Psychology, Tilburg University, The Netherlands.
Electroencephalogr Clin Neurophysiol. 1988 Mar;69(3):234-43. doi: 10.1016/0013-4694(88)90132-0.
Subjects had to press a button at regular intervals of 20 sec. Two seconds after each button press a stimulus was presented indicating the length of the past interval. EEG was analysed from 2500 msec preceding the button press until the presentation of the stimulus. Preceding the button press a readiness potential (RP) was recorded with amplitudes that were larger over the hemisphere contralateral to the movement side. Preceding the stimulus negative waves were recorded which were larger over the right hemisphere, irrespective of the movement side. In a warned reaction time experiment, the CNV late wave represents both motor preparation and stimulus anticipation. In the present study motor preparation and stimulus anticipation are no longer confounded factors. Thus, it is shown that stimulus anticipation is indeed reflected by negative activity, as is motor preparation. The potential distribution of the RP, however, is different from the stimulus-preceding negativity (SPN), a pointing to a different electrophysiological source. The potential distribution of the SPN has been investigated and a right hemisphere preponderance of the SPN has been found.
受试者必须每隔20秒按一次按钮。每次按下按钮两秒后，会呈现一个刺激，指示过去间隔的时长。脑电图分析的时间段是从按下按钮前2500毫秒到刺激出现之时。在按下按钮之前，会记录到准备电位（RP），其振幅在与运动侧对侧的半球上更大。在刺激出现之前，会记录到负波，这些负波在右半球上更大，与运动侧无关。在一个有提示的反应时实验中，关联性负变晚期波代表运动准备和刺激预期。在本研究中，运动准备和刺激预期不再是混杂因素。因此，研究表明刺激预期确实如运动准备一样由负性活动反映出来。然而，准备电位的电位分布与刺激前负性电位（SPN）不同，这表明存在不同的电生理来源。已经对刺激前负性电位的电位分布进行了研究，并发现刺激前负性电位在右半球占优势。
