马来酸曲美布汀对兔窦房结起搏活动的影响。

Effect of trimebutine maleate on sinus node pacemaker activity of the rabbit.

作者信息

Kotake H, Kinugawa T, Hirai S, Fukugi M, Hasegawa J, Mashiba H

机构信息

1st Department of Internal Medicine, Tottori University, Yonago, Japan.

出版信息

Eur J Pharmacol. 1987 Dec 15;144(3):327-30. doi: 10.1016/0014-2999(87)90385-2.

DOI:10.1016/0014-2999(87)90385-2

PMID:2450035

Abstract

The electrophysiological effects of trimebutine maleate were studied on rabbit sinus node cells with the two-microelectrode voltage clamp method. Trimebutine (above 10 microM) produced a negative chronotropic effect accompanied by decreases in the maximum upstroke velocity at phase 0, slope of phase 4 depolarization and action potential amplitude. The effects on the current systems were depression of the slow inward current and a decrease in the current oscillations induced by elevating [Ca]0. It is concluded that trimebutine exerts a Ca2+ channel blocking effect on the sinus node pacemaker cells.

摘要

采用双微电极电压钳法研究了马来酸曲美布汀对家兔窦房结细胞的电生理效应。曲美布汀（浓度高于10μM）产生负性变时作用，同时伴有0期最大除极速度、4期去极化斜率和动作电位幅度降低。对电流系统的影响为抑制慢内向电流以及升高[Ca]0诱导的电流振荡减少。结论是曲美布汀对窦房结起搏细胞发挥钙通道阻滞作用。