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关于刺激和阻断爪蟾皮肤肌上皮细胞α和β肾上腺素能受体对颗粒腺分泌影响的体外研究。

In vitro studies on the effects on granular gland secretion in Xenopus laevis skin of stimulation and blockade of alpha and beta adrenoceptors of myoepithelial cells.

作者信息

Holmes C H, Moondi P S, Rao R R, Balls M

出版信息

Cell Biol Int Rep. 1977 May;1(3):263-70. doi: 10.1016/0309-1651(77)90051-0.

DOI:10.1016/0309-1651(77)90051-0
PMID:24501
Abstract

Secretion from the granular glands of Xenopus laevis skin was stimulated by alpha-adrenergic agonists, an effect which was blocked by alpha-adrenergic antagonists and inhibited by beta-adrenergic agonists, db-cAMP and diazoxide. The inhibition by isoprenaline and salbutamol, but not that by diazoxide, was blocked by a beta-adrenergic antagonist. It is concluded that the myoepithelial cells surrounding the secretory compartment of the granular glands bear alpha and beta adrenoceptors, and that the beta receptors comprise, or at least include beta2 receptors.

摘要

非洲爪蟾皮肤颗粒腺的分泌受α-肾上腺素能激动剂刺激,该效应可被α-肾上腺素能拮抗剂阻断,并被β-肾上腺素能激动剂、二丁酰环磷腺苷(db-cAMP)和二氮嗪抑制。异丙肾上腺素和沙丁胺醇的抑制作用(但二氮嗪的抑制作用除外)可被β-肾上腺素能拮抗剂阻断。由此得出结论,颗粒腺分泌区周围的肌上皮细胞具有α和β肾上腺素能受体,且β受体包含或至少包括β2受体。

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