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（无尾目：蟾蜍科）皮肤粘性分泌物的流变学和生物学特性

Rheological and Biological Properties of Adhesive Skin Secretions from (Anura: Alsodidae).

作者信息

Contreras Felipe A, Sepúlveda Daniela P, Amaral André Capaldo, Nuñez José J, Trovatti Eliane, Suárez-Villota Elkin Y

机构信息

Instituto de Ciencias Naturales, Facultad de Medicina Veterinaria y Agronomía, Universidad de las Américas, Av. Jorge Alessandri No. 1160, Concepción, Chile.

Program of Post-Graduation in Regenerative Medicine and Medicinal Chemistry, University of Araraquara-UNIARA, Rua Carlos Gomes, Araraquara 1217, Brazil.

出版信息

Scientifica (Cairo). 2024 Mar 25;2024:2722351. doi: 10.1155/2024/2722351. eCollection 2024.

DOI:10.1155/2024/2722351
PMID:38566624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10985274/
Abstract

Skin secretions from Patagonian ground frogs, , have previously been reported as a potent proteinaceous adhesive with potential biomedical applications. Here, we conducted a rheological analysis indicating the mechanical robustness of these secretions, with a storage modulus ranging from 1 to 10 Pa. In addition, antimicrobial and cytotoxicity assays were performed, revealing no antimicrobial activity against both the Gram-positive and Gram-negative bacteria. The cytotoxicity results were intriguing, as three samples showed no harm, and one exhibited a severe cytotoxic effect on the human cell line MG63. These properties, as indicated by these preliminary results, reinforce their potential for practical applications in the industrial and medical sectors.

摘要

此前有报道称，巴塔哥尼亚地蛙的皮肤分泌物是一种具有潜在生物医学应用价值的强效蛋白质类粘合剂。在此，我们进行了流变学分析，结果表明这些分泌物具有机械稳定性，其储能模量在1至10帕斯卡之间。此外，我们还进行了抗菌和细胞毒性试验，结果显示对革兰氏阳性菌和革兰氏阴性菌均无抗菌活性。细胞毒性试验结果令人感兴趣，因为三个样本显示无危害，而一个样本对人类细胞系MG63表现出严重的细胞毒性作用。这些初步结果表明的这些特性，增强了它们在工业和医疗领域实际应用的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a696/10985274/13714de6e17c/SCIENTIFICA2024-2722351.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a696/10985274/ca138a44d2e6/SCIENTIFICA2024-2722351.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a696/10985274/24c366994f40/SCIENTIFICA2024-2722351.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a696/10985274/911845dad8cd/SCIENTIFICA2024-2722351.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a696/10985274/e6e53e83ae9a/SCIENTIFICA2024-2722351.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a696/10985274/13714de6e17c/SCIENTIFICA2024-2722351.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a696/10985274/ca138a44d2e6/SCIENTIFICA2024-2722351.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a696/10985274/24c366994f40/SCIENTIFICA2024-2722351.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a696/10985274/911845dad8cd/SCIENTIFICA2024-2722351.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a696/10985274/e6e53e83ae9a/SCIENTIFICA2024-2722351.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a696/10985274/13714de6e17c/SCIENTIFICA2024-2722351.005.jpg

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