Shemshian Maryam, Mousavi Seyed Hadi, Norouzy Abdolreza, Kermani Tayebe, Moghiman Toktam, Sadeghi Akram, Ghayour-Mobarhan Majid, Ferns Gordon A
J Complement Integr Med. 2014 Feb 6;11(1):43-9. doi: 10.1515/jcim-2013-0047.
The metabolic syndrome is the most important risk factor for cardiovascular disease. The heat shock proteins (HSPs) are highly conserved families of proteins expressed by a number of cell types following exposure to stressful environmental conditions include several known risk factors for cardiovascular disease. Recent studies have shown the potential of constituents of saffron in the treatment of atherosclerosis. We aimed on investigating the effect of saffron on antibody titers to HSP in patients with metabolic syndrome.
This was a randomized, placebo-controlled clinical trial. One-hundred and five subjects with metabolic syndrome were randomly allocated to one of the three groups: the case group received 100 mg/day saffron, the placebo control group received a capsule of placebo and a non-placebo control group received no capsule, for 12 weeks.
Antibodies against heat shock proteins 27, 60, 65 and 70 were determined in all patients before (week 0) and after (week 6 and 12) intervention. At 12 weeks, saffron produced a significantly decrease in AntiHSP27, 70 levels. Saffron can decrease AntiHSP27, 70 levels in patients with metabolic syndrome.
The results of this study indicate the efficacy of saffron in the improvement of some markers of autoimmunity HSPs in patients with metabolic syndrome.
代谢综合征是心血管疾病最重要的危险因素。热休克蛋白（HSPs）是高度保守的蛋白质家族，在多种细胞类型暴露于包括一些已知心血管疾病危险因素的应激环境条件后表达。最近的研究表明藏红花成分在治疗动脉粥样硬化方面具有潜力。我们旨在研究藏红花对代谢综合征患者热休克蛋白抗体滴度的影响。
这是一项随机、安慰剂对照的临床试验。105名代谢综合征患者被随机分配到三组之一：病例组每天服用100毫克藏红花，安慰剂对照组服用一粒安慰剂胶囊，非安慰剂对照组不服用胶囊，为期12周。
在所有患者干预前（第0周）和干预后（第6周和12周）测定了针对热休克蛋白27、60、65和70的抗体。在第12周时，藏红花使抗HSP27、70水平显著降低。藏红花可降低代谢综合征患者的抗HSP27、70水平。
本研究结果表明藏红花在改善代谢综合征患者自身免疫性热休克蛋白的一些标志物方面具有疗效。
