与皮下接种相比，卡介苗肺部接种可提供剂量依赖性的更强保护。
Pulmonary Mycobacterium bovis BCG vaccination confers dose-dependent superior protection compared to that of subcutaneous vaccination.
作者信息
Aguilo Nacho, Toledo Ana Maria, Lopez-Roman Eva Maria, Perez-Herran Esther, Gormley Eamonn, Rullas-Trincado Joaquin, Angulo-Barturen Iñigo, Martin Carlos
机构信息
Grupo de Genética de Micobacterias, Departmento de Microbiología, Medicina Preventiva y Salud Pública, Faculty of Medicine, Universidad de Zaragoza, Zaragoza, Spain.
出版信息
Clin Vaccine Immunol. 2014 Apr;21(4):594-7. doi: 10.1128/CVI.00700-13. Epub 2014 Feb 5.
Abstract
Worldwide, the Mycobacterium bovis BCG vaccine is one of the most widely used vaccines. However, it appears to be ineffective in preventing pulmonary tuberculosis. Here, we show that pulmonary BCG vaccination of mice with a broad dose range provides superior protection against Mycobacterium tuberculosis challenge compared to that of subcutaneous vaccination.
摘要
在全球范围内，牛分枝杆菌卡介苗（Mycobacterium bovis BCG）是使用最广泛的疫苗之一。然而，它在预防肺结核方面似乎无效。在此，我们表明，与皮下接种相比，对小鼠进行广泛剂量范围的肺部卡介苗接种能提供更好的针对结核分枝杆菌攻击的保护作用。
相似文献
1
Pulmonary Mycobacterium bovis BCG vaccination confers dose-dependent superior protection compared to that of subcutaneous vaccination.与皮下接种相比，卡介苗肺部接种可提供剂量依赖性的更强保护。
Clin Vaccine Immunol. 2014 Apr;21(4):594-7. doi: 10.1128/CVI.00700-13. Epub 2014 Feb 5.
2
Lymph node targeting of BCG vaccines amplifies CD4 and CD8 T-cell responses and protection against Mycobacterium tuberculosis.BCG 疫苗对淋巴结的靶向作用增强了针对结核分枝杆菌的 CD4 和 CD8 T 细胞应答和保护作用。
Vaccine. 2013 Feb 4;31(7):1057-64. doi: 10.1016/j.vaccine.2012.12.034. Epub 2012 Dec 25.
3
Single intranasal mucosal Mycobacterium bovis BCG vaccination confers improved protection compared to subcutaneous vaccination against pulmonary tuberculosis.与皮下接种卡介苗相比，单次鼻内黏膜接种牛分枝杆菌卡介苗对肺结核的保护作用更佳。
Infect Immun. 2004 Jan;72(1):238-46. doi: 10.1128/IAI.72.1.238-246.2004.
4
Accelerated induction of mycobacterial antigen-specific CD8+ T cells in the Mycobacterium tuberculosis-infected lung by subcutaneous vaccination with Mycobacterium bovis bacille Calmette-Guérin.经皮接种牛型结核分枝杆菌卡介苗加速结核分枝杆菌感染肺部中分枝杆菌抗原特异性 CD8+T 细胞的诱导。
Immunology. 2009 Dec;128(4):556-63. doi: 10.1111/j.1365-2567.2009.03141.x.
5
Protective efficacy of intranasal vaccination with Mycobacterium bovis BCG against airway Mycobacterium tuberculosis challenge in mice.牛分枝杆菌卡介苗鼻内接种对小鼠气道结核分枝杆菌攻击的保护效力
J Infect. 2006 Nov;53(5):350-6. doi: 10.1016/j.jinf.2005.12.017. Epub 2006 Jan 25.
6
Repeated Aerosolized-Boosting with Gamma-Irradiated Mycobacterium bovis BCG Confers Improved Pulmonary Protection against the Hypervirulent Mycobacterium tuberculosis Strain HN878 in Mice.用γ射线辐照的牛分枝杆菌卡介苗进行重复雾化加强免疫可增强小鼠对高毒力结核分枝杆菌菌株HN878的肺部保护作用。
PLoS One. 2015 Oct 28;10(10):e0141577. doi: 10.1371/journal.pone.0141577. eCollection 2015.
7
Vaccination against tuberculosis: how can we better BCG?结核疫苗接种：我们如何更好地使用卡介苗？
Microb Pathog. 2013 May;58:2-16. doi: 10.1016/j.micpath.2012.12.002. Epub 2012 Dec 17.
8
Loss of anti-mycobacterial efficacy in mice over time following vaccination with Mycobacterium bovis bacillus Calmette-Guérin.随着时间的推移，接种卡介苗后，小鼠对抗分枝杆菌的功效丧失。
Vaccine. 2011 Sep 16;29(40):6881-7. doi: 10.1016/j.vaccine.2011.07.051. Epub 2011 Jul 29.
9
Immunogenicity and protective efficacy against murine tuberculosis of a prime-boost regimen with BCG and a DNA vaccine expressing ESAT-6 and Ag85A fusion protein.卡介苗与表达ESAT-6和Ag85A融合蛋白的DNA疫苗初免-加强方案对小鼠结核病的免疫原性和保护效力
Clin Dev Immunol. 2011;2011:617892. doi: 10.1155/2011/617892. Epub 2011 Feb 27.
10
Mice fed lipid-encapsulated Mycobacterium bovis BCG are protected against aerosol challenge with Mycobacterium tuberculosis.喂食脂质包裹的牛分枝杆菌卡介苗的小鼠对结核分枝杆菌气溶胶攻击具有抵抗力。
Infect Immun. 2005 Mar;73(3):1903-5. doi: 10.1128/IAI.73.3.1903-1905.2005.
引用本文的文献
1
The frequency of CD38 alveolar macrophages correlates with early control of M. tuberculosis in the murine lung.CD38肺泡巨噬细胞的频率与小鼠肺部结核分枝杆菌的早期控制相关。
Nat Commun. 2024 Oct 2;15(1):8522. doi: 10.1038/s41467-024-52846-w.
2
CD38+ Alveolar macrophages mediate early control of M. tuberculosis proliferation in the lung.CD38+肺泡巨噬细胞介导对肺内结核分枝杆菌增殖的早期控制。
Res Sq. 2024 Jul 15:rs.3.rs-3934768. doi: 10.21203/rs.3.rs-3934768/v1.
3
Macrophages exploit the mannose receptor and JAK-STAT1-MHC-II pathway to drive antigen presentation and the antimycobacterial immune response after BCG vaccination.巨噬细胞利用甘露糖受体和 JAK-STAT1-MHC-II 途径来驱动抗原呈递和卡介苗接种后的抗分枝杆菌免疫反应。
Acta Biochim Biophys Sin (Shanghai). 2024 Jun 18;56(8):1130-1144. doi: 10.3724/abbs.2024100.
4
Intravenous BCG Vaccination of Diversity Outbred Mice Results in Moderately Enhanced Protection against Challenge with Mycobacterium tuberculosis Compared to Intradermal Vaccination.静脉内接种卡介苗（BCG）对多样性远交系小鼠的保护效果优于皮内接种，可适度增强其对结核分枝杆菌（Mycobacterium tuberculosis）的挑战保护作用。
Infect Immun. 2023 Jul 18;91(7):e0016823. doi: 10.1128/iai.00168-23. Epub 2023 Jun 20.
5
Advance in strategies to build efficient vaccines against tuberculosis.构建高效抗结核疫苗策略的进展
Front Vet Sci. 2022 Nov 24;9:955204. doi: 10.3389/fvets.2022.955204. eCollection 2022.
6
A century of BCG vaccination: Immune mechanisms, animal models, non-traditional routes and implications for COVID-19.一个世纪的卡介苗接种：免疫机制、动物模型、非传统途径及其对 COVID-19 的影响。
Front Immunol. 2022 Aug 26;13:959656. doi: 10.3389/fimmu.2022.959656. eCollection 2022.
7
Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung.组织驻留样 CD4+T 细胞分泌的白细胞介素-17 可控制人肺中的结核分枝杆菌。
J Clin Invest. 2021 May 17;131(10). doi: 10.1172/JCI142014.
8
Changes in the Immune Phenotype and Gene Expression Profile Driven by a Novel Tuberculosis Nanovaccine: Short and Long-Term Post-immunization.新型结核病纳米疫苗驱动的免疫表型和基因表达谱变化：免疫后短期和长期。
Front Immunol. 2021 Jan 28;11:589863. doi: 10.3389/fimmu.2020.589863. eCollection 2020.
9
Mycobacteria-Specific T Cells Are Generated in the Lung During Mucosal BCG Immunization or Infection With .在黏膜卡介苗免疫接种或感染 期间，肺部会产生分枝杆菌特异性 T 细胞。
Front Immunol. 2020 Oct 22;11:566319. doi: 10.3389/fimmu.2020.566319. eCollection 2020.
10
Next-Generation Pertussis Vaccines Based on the Induction of Protective T Cells in the Respiratory Tract.基于呼吸道中诱导保护性T细胞的新一代百日咳疫苗。
Vaccines (Basel). 2020 Oct 21;8(4):621. doi: 10.3390/vaccines8040621.
本文引用的文献
1
Recent developments in tuberculosis vaccines.结核病疫苗的最新进展。
Expert Rev Vaccines. 2013 Dec;12(12):1431-48. doi: 10.1586/14760584.2013.856765.
2
Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial.新型结核疫苗 MVA85A 在既往接种过卡介苗婴儿中的安全性和有效性：一项随机、安慰剂对照的 2b 期试验。
Lancet. 2013 Mar 23;381(9871):1021-8. doi: 10.1016/S0140-6736(13)60177-4.
3
WHO Informal Consultation on standardization and evaluation of BCG vaccines Geneva, Switzerland 22-23 September 2009.世界卫生组织关于卡介苗疫苗标准化和评估的非正式磋商 瑞士日内瓦 2009 年 9 月 22-23 日
Vaccine. 2010 Oct 8;28(43):6945-50. doi: 10.1016/j.vaccine.2010.07.086. Epub 2010 Aug 6.
4
Immunogenicity and protective efficacy of "Mycobacterium w" against Mycobacterium tuberculosis in mice immunized with live versus heat-killed M. w by the aerosol or parenteral route.通过气溶胶或肠胃外途径用活的与热灭活的“W型分枝杆菌”免疫小鼠后，“W型分枝杆菌”对结核分枝杆菌的免疫原性和保护效力。
Infect Immun. 2009 Jan;77(1):223-31. doi: 10.1128/IAI.00526-08. Epub 2008 Nov 3.
5
Should a new tuberculosis vaccine be administered intranasally?新型结核病疫苗应该通过鼻腔给药吗？
Tuberculosis (Edinb). 2007 Jul;87(4):257-66. doi: 10.1016/j.tube.2006.12.006. Epub 2007 Feb 26.
6
CD27low CD4 T lymphocytes that accumulate in the mouse lungs during mycobacterial infection differentiate from CD27high precursors in situ, produce IFN-gamma, and protect the host against tuberculosis infection.在分枝杆菌感染期间在小鼠肺部积聚的CD27低表达CD4 T淋巴细胞在原位从CD27高表达前体分化而来，产生γ干扰素，并保护宿主免受结核感染。
J Immunol. 2007 Jan 15;178(2):976-85. doi: 10.4049/jimmunol.178.2.976.
7
The success and failure of BCG - implications for a novel tuberculosis vaccine.卡介苗的成败——对新型结核病疫苗的启示
Nat Rev Microbiol. 2005 Aug;3(8):656-62. doi: 10.1038/nrmicro1211.
8
Intranasal bacille Calmette-Guerin (BCG) vaccine dosage needs balancing between protection and lung pathology.鼻内卡介苗（BCG）疫苗的剂量需要在保护作用和肺部病理之间取得平衡。
Clin Exp Immunol. 2004 Dec;138(3):405-9. doi: 10.1111/j.1365-2249.2004.02648.x.
9
CD4 T cells producing IFN-gamma in the lungs of mice challenged with mycobacteria express a CD27-negative phenotype.在用分枝杆菌攻击的小鼠肺部产生γ干扰素的CD4 T细胞表现出CD27阴性表型。
Clin Exp Immunol. 2004 Oct;138(1):21-9. doi: 10.1111/j.1365-2249.2004.02573.x.
10
Paucibacillary tuberculosis in mice after prior aerosol immunization with Mycobacterium bovis BCG.用牛分枝杆菌卡介苗进行气溶胶免疫后小鼠的少菌型结核病
Infect Immun. 2004 Feb;72(2):1065-71. doi: 10.1128/IAI.72.2.1065-1071.2004.
Zotero 插件