作为抗原的抗体。利用小鼠单克隆抗体使人类T细胞聚焦于选定靶点。
Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets.
作者信息
Lanzavecchia A, Abrignani S, Scheidegger D, Obrist R, Dörken B, Moldenhauer G
机构信息
Basel Institute for Immunology, Switzerland.
出版信息
J Exp Med. 1988 Feb 1;167(2):345-52. doi: 10.1084/jem.167.2.345.
Abstract
We found that three tumor patients treated with mouse mAbs have T cells that recognize processed mouse Ig on autologous APC in a class II-restricted fashion, and we have shown that mouse mAbs directed against various cell surface molecules can be used as antigens to focus these T cells on an MHC class II-positive target of choice.
摘要
我们发现，三名接受小鼠单克隆抗体治疗的肿瘤患者体内的T细胞能够以II类限制性方式识别自体抗原呈递细胞（APC）上处理过的小鼠免疫球蛋白（Ig），并且我们已经证明，针对各种细胞表面分子的小鼠单克隆抗体可作为抗原，将这些T细胞聚焦于选定的MHC II类阳性靶标上。
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Utilization of monoclonal antibodies in the treatment of leukemia and lymphoma.单克隆抗体在白血病和淋巴瘤治疗中的应用。
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