Department of Nephrology, Ghent University Hospital, Gent, Belgium.
Department of Nephrology, Ghent University Hospital, Gent, Belgium.
Ageing Res Rev. 2014 Mar;14:1-18. doi: 10.1016/j.arr.2014.01.006. Epub 2014 Feb 3.
As aging is a complex phenomenon characterized by intraindividual and interindividual diversities in the maintenance of the homeostatic condition of cells and tissues, changes in renal function are not uniform and depend on associated diseases and environmental factors. Multiple studies have investigated the possible underlying mechanisms of age-related decline in kidney function. Evolutionary, molecular, cellular and systemic theories have been postulated to explain the primary disease independent age-related changes and adaptive responses. As peroxisome proliferator-activated receptors (PPARs) are involved in a broad spectrum of biological processes, PPAR activation might have an effect on the prevention of cell senescence. In this review, we will focus on the experimental and clinical evidence of PPAR agonists in a battle against the aging kidney.
随着衰老成为一种复杂的现象，其特点是细胞和组织的内个体和个体间的稳态维持存在差异，肾功能的变化并不统一，取决于相关疾病和环境因素。多项研究已经探讨了可能导致肾功能随年龄下降的潜在机制。进化、分子、细胞和系统理论被提出来解释与原发性疾病无关的与年龄相关的变化和适应性反应。由于过氧化物酶体增殖物激活受体（PPARs）参与了广泛的生物学过程，PPAR 激活可能对预防细胞衰老有影响。在这篇综述中，我们将重点关注 PPAR 激动剂在对抗衰老肾脏方面的实验和临床证据。
