Na Donghui, Zhang Zechen, Meng Meng, Li Meiyu, Gao Junyan, Kong Jiming, Zhang Guohui, Guo Ying
Department of Forensic Medicine, Hebei North University, Zhangjiakou, Hebei, China.
Mudi Meng Honors College, China Pharmaceutical University, Nanjing, Jiangsu, China.
Cell Mol Neurobiol. 2025 Apr 21;45(1):38. doi: 10.1007/s10571-025-01555-z.
Aging is characterized by a gradual decline in physiological functions, with brain aging being a major risk factor for numerous neurodegenerative diseases. Given the brain's high energy demands, maintaining an adequate ATP supply is crucial for its proper function. However, with advancing age, mitochondria dysfunction and a deteriorating energy metabolism lead to reduced overall energy production and impaired mitochondrial quality control (MQC). As a result, promoting healthy aging has become a key focus in contemporary research. This review examines the relationship between energy metabolism and brain aging, highlighting the connection between MQC and energy metabolism, and proposes strategies to delay brain aging by targeting energy metabolism.
衰老的特征是生理功能逐渐衰退，而大脑衰老是众多神经退行性疾病的主要风险因素。鉴于大脑对能量的高需求，维持充足的ATP供应对其正常功能至关重要。然而，随着年龄的增长，线粒体功能障碍和能量代谢恶化导致整体能量产生减少以及线粒体质量控制（MQC）受损。因此，促进健康衰老已成为当代研究的关键重点。本综述探讨了能量代谢与大脑衰老之间的关系，强调了MQC与能量代谢之间的联系，并提出了通过针对能量代谢来延缓大脑衰老的策略。
