Laboratory of Influenza Research, Chungnam National University, College of Veterinary Medicine, 220 Gung Dong, Daejeon 305-764, Republic of Korea; Institute for Influenza Virus, Chungnam National University, College of Veterinary Medicine, 220 Gung Dong, Daejeon 305-764, Republic of Korea.
Laboratory of Public Health, Chungnam National University, College of Veterinary Medicine, Daejeon 305-764, Republic of Korea.
Virology. 2014 Feb;450-451:316-23. doi: 10.1016/j.virol.2013.12.022. Epub 2014 Jan 14.
Previous studies have shown that the H7N9 avian influenza virus cannot be transmitted efficiently between ferrets via respiratory droplets. Here, we studied the infectivity of the H7N9 avian influenza virus in chickens and its transmissibility from infected to naïve chickens and ferrets. The H7N9 virus (A/Anhui/1/2013) replicated poorly in chickens and could not be transmitted efficiently from infected chickens to naïve chickens and ferrets. H7N9 virus was shed from chicken tracheae for only 2 days after infection and from chicken cloacae for only 1 day after infection, while the H9N2 avian influenza virus, which is endemic in chickens in many Asian countries, was shed from tracheae and cloacae for 8 days after infection. Taken together, our results suggest that chickens may be a poor agent of transmission for the H7N9 virus to other chickens and to mammals, including humans.
先前的研究表明，H7N9 禽流感病毒不能通过呼吸道飞沫在雪貂之间有效地传播。在这里，我们研究了 H7N9 禽流感病毒在鸡中的感染性及其从感染鸡向未感染鸡和雪貂的传播性。H7N9 病毒（A/Anhui/1/2013）在鸡中复制能力差，不能有效地从感染鸡传播给未感染鸡和雪貂。H7N9 病毒在感染后仅从鸡气管中排出 2 天，从鸡泄殖腔中排出 1 天，而在许多亚洲国家鸡中流行的 H9N2 禽流感病毒在感染后从气管和泄殖腔中排出 8 天。综上所述，我们的研究结果表明，鸡可能是 H7N9 病毒向其他鸡和哺乳动物（包括人类）传播的不良媒介。
