Hökfelt T, Wiesenfeld-Hallin Z, Villar M, Melander T
Department of Histology, Karolinska Institute, Stockholm, Sweden.
Neurosci Lett. 1987 Dec 29;83(3):217-20. doi: 10.1016/0304-3940(87)90088-7.
The L4 and L5 dorsal root ganglia were studied in untreated rats and rats subjected to unilateral transection of the sciatic nerve, using the indirect immunofluorescence technique and antibodies to the peptide galanin (GAL). In control rats only low numbers of small ganglion cells contained GAL-like immunoreactivity (LI). After axotomy a marked increase in the number and intensity of GAL-immunoreactive ganglion cell bodies was seen on the lesion side. Thus, some primary sensory neurons react to transection of their peripheral branches by expressing increased GAL levels. A similar reaction has been described by other groups for vasoactive intestinal polypeptide.
使用间接免疫荧光技术和抗甘丙肽（GAL）肽抗体，对未处理的大鼠以及坐骨神经单侧横断的大鼠的L4和L5背根神经节进行了研究。在对照大鼠中，只有少量小神经节细胞含有GAL样免疫反应性（LI）。轴突切断后，在损伤侧可见GAL免疫反应性神经节细胞体的数量和强度显著增加。因此，一些初级感觉神经元通过表达增加的GAL水平对其外周分支横断作出反应。其他研究小组对血管活性肠肽也描述了类似的反应。
