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一种用于计算自由浮动模式(FFF)光子束体模散射因子的解析方法。

An analytical formalism to calculate phantom scatter factors for flattening filter free (FFF) mode photon beams.

机构信息

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

出版信息

Phys Med Biol. 2014 Feb 21;59(4):951-60. doi: 10.1088/0031-9155/59/4/951. Epub 2014 Feb 7.

Abstract

Phantom Scatter Factors, Sp in the Khan formalism (Khan et al 1980 J. Radiat. Oncol. Biol. Phys. 6 745-51) describe medium-induced changes in photon-beam intensity as a function of size of the beam. According to the British Journal of Radiology, Supplement 25, megavoltage phantom scatter factors are invariant as a function of photon-beam energy. However, during the commissioning of an accelerator with flattening filter free (FFF) photon beams (Varian TrueBeam(TM) 6-MV FFF and 10-MV FFF), differences were noted in phantom scatter between the filtered beams and FFF-mode beams. The purpose of this work was to evaluate this difference and provide an analytical formalism to explain the phantom scatter differences between FFF-mode and the filtered mode. An analytical formalism was devised to demonstrate the source of phantom scatter differences between the filtered and the FFF-mode beams. The reason for the differences in the phantom scatter factors between the filtered and the FFF-mode beams is hypothesized to be the non-uniform beam profiles of the FFF-mode beams. The analytical formalism proposed here is based on this idea, taking the product of the filtered phantom scatter factors and the ratio of the off-axis ratio between the FFF-mode and the filtered beams. All measurements were performed using a Varian TrueBeam(TM) linear accelerator with photon energies of 6-MV and 10-MV in both filtered and FFF-modes. For all measurements, a PTW Farmer type chamber and a Scanditronix CC04 cylindrical ionization were used. The in-water measurements were made at depth dose maximum and 100 cm source-to-axis distance. The in-air measurements were done at 100 cm source-to-axis distance with appropriate build-up cap. From these measurements, the phantom scatter factors were derived for the filtered beams and the FFF-mode beams for both energies to be evaluated against the phantoms scatter factors calculated using the proposed algorithm. For 6-MV, the difference between the measured and the calculated FFF-mode phantom scatter factors ranged from -0.34% to 0.73%. The average per cent difference was -0.17% (1σ = 0.25%). For 10-MV, the difference ranged from -0.19% to 0.24%. The average per cent difference was -0.17% (1σ = 0.13%). An analytical formalism was presented to calculate the phantom scatter factors for FFF-mode beams using filtered phantom scatter factors as a basis. The overall differences between measurements and calculations were within ± 0.5% for 6-MV and ± 0.25% for 10-MV.

摘要

幻影散射因子,Khan 形式主义中的自旋(Khan 等人,1980 年,《放射肿瘤生物学物理杂志》,6745-51)描述了作为光束大小函数的光子束强度的介质诱导变化。根据《英国放射学杂志》增刊 25,兆伏级幻影散射因子作为光子束能量的函数是不变的。然而,在使用带有平坦滤波器的加速器进行调试时(Varian TrueBeam(TM)6-MV FFF 和 10-MV FFF),在过滤光束和 FFF 模式光束之间注意到了幻影散射的差异。这项工作的目的是评估这种差异,并提供一个分析公式来解释 FFF 模式和过滤模式之间的幻影散射差异。设计了一个分析公式来证明过滤模式和 FFF 模式之间的幻影散射差异的来源。过滤模式和 FFF 模式之间的幻影散射因子差异的原因被假设为 FFF 模式光束的非均匀光束轮廓。这里提出的分析公式基于这一想法,取过滤模式的幻影散射因子的乘积和 FFF 模式与过滤模式之间的离轴比的比值。所有测量均使用 Varian TrueBeam(TM)线性加速器在过滤和 FFF 模式下进行,光子能量为 6-MV 和 10-MV。对于所有测量,均使用 PTW Farmer 型室和 Scanditronix CC04 圆柱形电离室进行。在水深剂量最大值和 100cm 源轴距离处进行水中测量。在 100cm 源轴距离处进行空气测量,并使用适当的建堆帽。根据这些测量,为过滤光束和两种能量的 FFF 模式光束导出了幻影散射因子,以便与使用所提出的算法计算的幻影散射因子进行比较。对于 6-MV,测量值与计算值之间的 FFF 模式幻影散射因子差异范围为-0.34%至 0.73%。平均百分比差异为-0.17%(1σ=0.25%)。对于 10-MV,差异范围为-0.19%至 0.24%。平均百分比差异为-0.17%(1σ=0.13%)。提出了一种分析公式,用于使用过滤模式的幻影散射因子作为基础,计算 FFF 模式光束的幻影散射因子。6-MV 的测量值与计算值之间的总体差异在±0.5%以内,10-MV 的测量值与计算值之间的总体差异在±0.25%以内。

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