Manus Biosynthesis, 790 Memorial Drive, Suite 102, Cambridge, MA 02139, USA.
Manus Biosynthesis, 790 Memorial Drive, Suite 102, Cambridge, MA 02139, USA; Centre for Industrial Biotechnology and Biocatalysis, Ghent University, Coupure Links 653, B-9000, Belgium.
Curr Opin Biotechnol. 2014 Apr;26:155-61. doi: 10.1016/j.copbio.2014.01.004. Epub 2014 Feb 3.
The increasing public awareness of adverse health impacts from excessive sugar consumption has created increasing interest in plant-derived, natural low-calorie or zero-calorie sweeteners. Two plant species which contain natural sweeteners, Stevia rebaudiana and Siraitia grosvenorii, have been extensively profiled to identify molecules with high intensity sweetening properties. However, sweetening ability does not necessarily make a product viable for commercial applications. Some criteria for product success are proposed to identify which targets are likely to be accepted by consumers. Limitations of plant-based production are discussed, and a case is put forward for the necessity of biotechnological production methods such as plant cell culture or microbial fermentation to meet needs for commercial-scale production of natural sweeteners.
公众对过量糖摄入对健康产生不良影响的认识不断提高，促使人们对植物来源的天然低热量或零热量甜味剂越来越感兴趣。甜菊和罗汉果这两种含有天然甜味剂的植物已被广泛研究，以鉴定具有高强度甜味特性的分子。然而，甜味能力并不一定使产品具有商业应用的可行性。提出了一些产品成功的标准，以确定哪些目标可能被消费者接受。讨论了基于植物的生产的局限性，并提出了生物技术生产方法（如植物细胞培养或微生物发酵）的必要性，以满足商业规模生产天然甜味剂的需求。
