[为何在儿童肺病学中使用长期大环内酯类药物治疗？]

[Why use long-term macrolide therapy in pediatric pulmonology?].

作者信息

Corvol H, Taytard J, Thouvenin G, Périsson C, Nathan N, Clement A

机构信息

Service de pneumologie pédiatrique, hôpital Trousseau, AP-HP, centre de ressources et de compétences pour la mucoviscidose, centre de référence des maladies respiratoires rares, université Pierre-et-Marie-Curie-Paris 6, unité Inserm U938, 26, avenue du Dr-Netter, 75012 Paris, France.

出版信息

Arch Pediatr. 2014 Mar;21(3):314-21. doi: 10.1016/j.arcped.2013.12.023. Epub 2014 Feb 3.

DOI:10.1016/j.arcped.2013.12.023

PMID:24503457

Abstract

Macrolides are well-known antibiotics exerting antimicrobial as well as anti-inflammatory and immunomodulatory effects. Since the observation of a dramatic improvement in lung disease and survival in patients with diffuse panbronchiolitis, macrolides have been used over the long term in several chronic respiratory diseases. This review describes the results of trials that have evaluated long-term macrolides in the treatment of cystic fibrosis, non-cystic fibrosis bronchiectasis, and asthma, particularly focusing on the impact on children. It also provides new insights on the potential effects of macrolides on diffuse parenchymal lung diseases.

摘要

大环内酯类是众所周知的抗生素，具有抗菌以及抗炎和免疫调节作用。自从观察到弥漫性泛细支气管炎患者的肺部疾病和生存率有显著改善以来，大环内酯类已长期用于多种慢性呼吸道疾病。这篇综述描述了评估长期使用大环内酯类治疗囊性纤维化、非囊性纤维化支气管扩张和哮喘的试验结果，特别关注对儿童的影响。它还提供了关于大环内酯类对弥漫性实质性肺疾病潜在影响的新见解。