Dalsgaard C J, Jonsson C E, Haegerstrand A, Brodin E
Department of Anatomy, Karolinska Institute, Stockholm, Sweden.
Scand J Plast Reconstr Surg Hand Surg. 1987;21(3):291-2. doi: 10.3109/02844318709086463.
The role of primary sensory neuropeptides in experimental burns was investigated. It was shown that after scalding, substance P-like immunoreactivity is released into the lymphatic fluid of dogs. Substance P, injected intravenously, was shown to cause dose-dependent oedema formation in rat skin, as measured with the Evans blue-technique. Furthermore, capsaicin pretreatment, which depletes the neuropeptide content of primary sensory neurons, was shown to inhibit late oedema formation in rats.
研究了初级感觉神经肽在实验性烧伤中的作用。结果表明，烫伤后，P物质样免疫反应性释放到犬的淋巴液中。静脉注射P物质后，用伊文思蓝技术测量显示，其可引起大鼠皮肤剂量依赖性水肿形成。此外，辣椒素预处理可耗尽初级感觉神经元的神经肽含量，结果显示其可抑制大鼠后期水肿形成。
