Allen J, Hansen V, Maigaard S, Andersson K E, Forman A
Department of Obstetrics and Gynecology, University of Aarhus, Denmark.
Am J Obstet Gynecol. 1988 Mar;158(3 Pt 1):637-41. doi: 10.1016/0002-9378(88)90045-2.
Human cervical tissue specimens were excised after hysterectomy at various phases of the menstrual cycle (n = 12), and small intracervical arteries were dissected free by microtechnique. Ring preparations of the vessels were prepared and mounted in organ baths, and isometric circular tension was recorded. Norepinephrine, 3 X 10(-8) to 10(-5) mol/L, produced concentration-dependent contractions, whereas 3 X 10(-7) to 10(-6) mol/L prostaglandin F2 alpha inconsistently produced weak contractions and slightly increased tension induced by 10(-5) mol/L norepinephrine. Prostaglandin I2, 10(-9) to 10(-6) mol/L, prostaglandin E2, 3 X 10(-9) to 10(-6) mol/L, vasoactive intestinal polypeptide, 10(-9) to 10(-7) mol/L, and substance P, 10(-12) to 10(-9) mol/L, induced relaxation of vessels precontracted by 10(-5) mol/L norepinephrine. It is suggested that several mechanisms for the local release of vasoactive compounds may influence cervical blood flow. Thus, sympathetic control of cervical blood flow may be modulated by peptide neurotransmitters such as vasoactive intestinal polypeptide and substance P and by local synthesis of prostaglandins E2 and I2.
在月经周期的不同阶段进行子宫切除术后，获取人体宫颈组织标本（n = 12），采用显微技术游离出宫颈内小动脉。制备血管的环行标本并置于器官浴槽中，记录等长的环形张力。去甲肾上腺素浓度为3×10⁻⁸至10⁻⁵mol/L时可产生浓度依赖性收缩，而前列腺素F2α浓度为3×10⁻⁷至10⁻⁶mol/L时，产生的收缩作用不恒定且较弱，同时可使10⁻⁵mol/L去甲肾上腺素诱导的张力略有增加。前列腺素I2浓度为10⁻⁹至10⁻⁶mol/L、前列腺素E2浓度为3×10⁻⁹至10⁻⁶mol/L、血管活性肠肽浓度为10⁻⁹至10⁻⁷mol/L以及P物质浓度为10⁻¹²至10⁻⁹mol/L时，均可使由10⁻⁵mol/L去甲肾上腺素预收缩的血管舒张。提示血管活性化合物的局部释放的几种机制可能影响宫颈血流。因此，宫颈血流的交感神经控制可能受到肽类神经递质如血管活性肠肽和P物质以及前列腺素E2和I2的局部合成的调节。
