Hansen V, Schifter S, Allen J, Maigaard S, Forman A
Department of Obstetrics and Gynecology, University of Aarhus, Denmark.
Gynecol Obstet Invest. 1988;25(4):258-61. doi: 10.1159/000293795.
The contractile effects of substance P and human calcitonin gene-related peptide (human CGRP) on isolated human intracervical arteries were studied. Human cervical tissue specimens were excised after hysterectomy at various phases of the menstrual cycle (n = 14) and small intracervical arteries were dissected free by microtechnique. Ring preparations of the vessels were prepared and mounted in organ baths, and isometric circular tension was recorded. Neither compound affected resting tension. Both peptides showed potent relaxing effects on vessels precontracted by noradrenaline 10(-5) M. Substance P exhibited the higher potency, while human CGRP showed the higher efficacy. The relaxing effects of the two compounds were unaffected by pretreatment with indomethacin 10(-6) M, propranolol 10(-6) M and atropine 10(-6) M. The results support a role for the two peptides in the regulation of cervical blood flow.
研究了P物质和人降钙素基因相关肽（人CGRP）对离体人宫颈动脉的收缩作用。在月经周期的不同阶段（n = 14）进行子宫切除术后切除人宫颈组织标本，通过显微技术分离出小的宫颈内动脉。制备血管的环行标本并安装在器官浴槽中，记录等长的圆周张力。两种化合物均不影响静息张力。两种肽对10(-5) M去甲肾上腺素预收缩的血管均显示出强效的舒张作用。P物质表现出更高的效价，而人CGRP显示出更高的效能。两种化合物的舒张作用不受10(-6) M吲哚美辛、10(-6) M普萘洛尔和10(-6) M阿托品预处理的影响。结果支持这两种肽在调节宫颈血流中起作用。
