推出 MINA——分子印迹纳米颗粒分析。
Introducing MINA--The Molecularly Imprinted Nanoparticle Assay.
机构信息
Saint-Petersburg State, Chemical-Pharmaceutical Academy, Saint-Petersburg, Prof. Popov St. 14, 197376, Russian Federation.
出版信息
Small. 2014 Mar 26;10(6):1086-9. doi: 10.1002/smll.201301996. Epub 2014 Feb 6.
Abstract
A new ELISA- (enzyme-linked immunosorbent assay)-like assay is demonstrated in which no elements of biological origin are used for molecular recognition or signaling. Composite imprinted nanoparticles that contain a catalytic core and which are synthesized by using a solid-phase approach can simultaneously act as recognition/signaling elements, and be used with minimal modifications to standard assay protocols. This assay provides a new route towards replacement of unstable biomolecules in immunoassays.
摘要
一种新型的酶联免疫吸附测定（ELISA）类似测定方法被展示出来，其中没有使用任何生物起源的元素进行分子识别或信号传递。通过固相方法合成的包含催化核心的复合印迹纳米粒子可以同时充当识别/信号传递元素，并可以进行最小的修改，应用于标准测定方案中。该测定方法为免疫测定中不稳定生物分子的替代提供了新途径。
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