中性粒细胞功能障碍：概述

Disorders of neutrophil function: an overview.

作者信息

Dinauer Mary C

机构信息

Departments of Pediatrics (Hematology/Oncology) and Pathology & Immunology, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, USA.

出版信息

Methods Mol Biol. 2014;1124:501-15. doi: 10.1007/978-1-62703-845-4_30.

DOI:10.1007/978-1-62703-845-4_30

PMID:24504971

Abstract

Primary disorders of neutrophil function result from impairment in neutrophil responses that are critical for host defense. This chapter summarizes inherited disorders of neutrophils that cause defects in neutrophil adhesion, migration, and oxidative killing. These include the leukocyte adhesion deficiencies, actin defects, and other disorders of chemotaxis, hyperimmunoglobulin E syndrome, Chédiak-Higashi syndrome, neutrophil-specific granule deficiency, chronic granulomatous disease, and myeloperoxidase deficiency. Diagnostic tests and treatment approaches are also summarized for each neutrophil disorder.

摘要

中性粒细胞功能原发性障碍源于对宿主防御至关重要的中性粒细胞反应受损。本章总结了导致中性粒细胞黏附、迁移和氧化杀伤缺陷的遗传性中性粒细胞疾病。这些疾病包括白细胞黏附缺陷、肌动蛋白缺陷及其他趋化性障碍、高免疫球蛋白E综合征、切-东综合征、中性粒细胞特异性颗粒缺乏症、慢性肉芽肿病和髓过氧化物酶缺乏症。还总结了每种中性粒细胞疾病的诊断测试和治疗方法。