Dallas Baptist University, 3000 Mountain Creek Pkwy, Dallas, TX 75211, United States.
Math Biosci Eng. 2014 Jun;11(3):471-509. doi: 10.3934/mbe.2014.11.471.
This study presents a metapopulation model for the sylvatic transmission of Trypanosoma cruzi, the etiological agent of Chagas' disease, across multiple geographical regions and multiple overlapping host-vector transmission cycles. Classical qualitative analysis of the model and several submodels focuses on the parasite's basic reproductive number, illustrating how vector migration across patches and multiple transmission routes to hosts (including vertical transmission) determine the infection's persistence in each cycle. Numerical results focus on trends in endemic [equilibrium] persistence levels as functions of vector migration rates, and highlight the significance of the different epidemiological characteristics of transmission in each of the three regions.
本研究提出了一个关于克氏锥虫（恰加斯病的病原体）在多个地理区域和多个重叠的宿主-媒介传播周期中的森林传播的集合种群模型。对模型和几个子模型的经典定性分析侧重于寄生虫的基本繁殖数，说明了媒介在斑块之间的迁移以及向宿主的多种传播途径（包括垂直传播）如何决定每个周期中的感染持续存在。数值结果主要关注作为媒介迁移率函数的地方病[平衡]持续存在水平的趋势，并强调了三个区域中每种传播的不同流行病学特征的重要性。
