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[轻度阻塞性睡眠呼吸暂停患者中快速眼动相关阻塞性睡眠呼吸暂停的频率及特征]

[The frequency and properties of REM related obstructive sleep apnea among the patients with mild related obstructive sleep apnea].

作者信息

Kutbay Özçelik Hatice, Akkoyunlu Muhammed Emin, Bostanlı Pınar, Bayram Mehmet, Atahan Ersan, Sezer Murat, Karaköse Fatmanur, Kart Levent

机构信息

Department of Chest Diseases, Faculty of Medicine, Bezmialem Vakıf University, Istanbul, Turkey.

出版信息

Tuberk Toraks. 2013;61(4):283-7. doi: 10.5578/tt.6208.

DOI:10.5578/tt.6208
PMID:24506743
Abstract

INTRODUCTION

The question if REM related obstructive sleep apnea (OSA) is a specific clinical entity or if it is an early sign of severe sleep disordered breathing as there is high occurrence of REM OSA in mild and moderate cases, recently have attracted the investigators. In this study, we aimed to see the frequency of REM related OSA among patients with mild OSA; and also to evaluate relation between apnea and daytime sleepiness among REM related OSA patients.

MATERIALS AND METHODS

One hundred thirty four patients with mild OSA [Apnea hipopnea index (AHI)= 5-15] among 1267 patients with polysomnography examination at sleep laboratory of Bezmialem University Hospital between 1st August 2010 and 29th February 2012 were retrospectively evaluated. Patients having REM AHI/non-REM AHI ≥ 2 and non-REM AHI < 15 are considered as REM related OSA.

RESULTS

Eighty (59%) of 134 patients with mild OSA were considered as REM related OSA. When REM related OSA and non REM OSA are compared for age, gender, daytime sleepiness, body mass index, neck surround and aditional diseases; mean age of REM related OSA group was found only significantly lower. Number of AHI in REM was over 15 at 87.3% of REM related OSA group and over 30 at 39.3% of them. There was no relation between REM AHI and daytime sleepiness symptom (p= 0.81).

CONCLUSION

We may consider the result of lower mean age in REM related OSA group as a supporting result for early sign of severe sleep disordered breathing. We consider to follow up this group of patients to answer the question about subject.

摘要

引言

快速眼动(REM)相关的阻塞性睡眠呼吸暂停(OSA)是一种特定的临床实体,还是严重睡眠呼吸紊乱的早期迹象,由于轻度和中度病例中REM OSA的发生率较高,这一问题最近引起了研究人员的关注。在本研究中,我们旨在了解轻度OSA患者中REM相关OSA的发生率;并评估REM相关OSA患者呼吸暂停与日间嗜睡之间的关系。

材料与方法

回顾性评估2010年8月1日至2012年2月29日在贝兹米阿勒姆大学医院睡眠实验室进行多导睡眠图检查的1267例患者中的134例轻度OSA患者[呼吸暂停低通气指数(AHI)=5-15]。REM AHI/非REM AHI≥2且非REM AHI<15的患者被视为REM相关OSA。

结果

134例轻度OSA患者中有80例(59%)被视为REM相关OSA。比较REM相关OSA和非REM OSA患者的年龄、性别、日间嗜睡、体重指数、颈围和其他疾病;发现REM相关OSA组的平均年龄仅显著较低。REM相关OSA组中87.3%的患者REM期AHI超过15,其中39.3%的患者超过30。REM AHI与日间嗜睡症状之间无相关性(p=0.81)。

结论

我们可以将REM相关OSA组平均年龄较低的结果视为严重睡眠呼吸紊乱早期迹象的支持性结果。我们考虑对这组患者进行随访,以回答关于该主题的问题。

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[Supine position and REM dependence in obstructive sleep apnea. Critical model considerations. German version].
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