Lee Sang-Ahm, Paek Joon-Hyun, Han Su-Hyun
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, South Korea.
Sleep Breath. 2016 Sep;20(3):995-1002. doi: 10.1007/s11325-016-1323-2. Epub 2016 Mar 11.
The purposes of the present study are to determine the prevalence and demographic features of rapid eye movement (REM)-related sleep-disordered breathing (SDB) in Korean adults with newly diagnosed obstructive sleep apnea (OSA) and determine if REM-related SDB is associated with depressive symptoms and health-related quality of life (HRQoL) in OSA patients.
In this cross-sectional study, we evaluated 1281 OSA adults who were consecutively recruited. REM-related SDB was defined as an overall apnea-hypopnea index (AHI) ≥5, an AHINREM <15, and AHIREM to AHINREM ratio of >2. The Epworth Sleepiness Scale (ESS), Beck Depression Inventory (BDI), and Medical Outcomes Study Short-Form Health survey (SF-36) were used to evaluate all patients. Multiple regression analyses were performed to determine the associations between REM-related SDB and clinical outcomes.
The prevalence of REM-related SDB was 18 % in this study. REM-related SDB was more commonly observed in patients with mild or moderate OSA (p < 0.001) and women (p < 0.001). The linear regression analysis showed that the presence of REM-related SDB was significantly associated with higher BDI scores, but only in men. AHIREM was positively associated with the BDI scores, but only in men with REM-related SDB. There were no differences in ESS and SF-36 scores between patients with and without REM-related SDB.
Patients with REM-related SDB account for 18 % of Korean OSA adults. REM-related SDB was associated with depressive symptoms, but only in men. AHIREM is positively related to the degree of depressive symptoms in men with REM-related SDB.
本研究旨在确定新诊断为阻塞性睡眠呼吸暂停（OSA）的韩国成年人中快速眼动（REM）相关睡眠呼吸障碍（SDB）的患病率及人口统计学特征，并确定REM相关SDB是否与OSA患者的抑郁症状及健康相关生活质量（HRQoL）相关。
在这项横断面研究中，我们评估了连续招募的1281名OSA成年人。REM相关SDB定义为总体呼吸暂停低通气指数（AHI）≥5、非快速眼动期AHI（AHI NREM）<15且快速眼动期AHI与非快速眼动期AHI之比>2。使用爱泼沃斯嗜睡量表（ESS）、贝克抑郁量表（BDI）和医学结局研究简明健康调查（SF-36）对所有患者进行评估。进行多元回归分析以确定REM相关SDB与临床结局之间的关联。
本研究中REM相关SDB的患病率为18%。REM相关SDB在轻度或中度OSA患者（p<0.001）和女性（p<0.001）中更常见。线性回归分析表明，REM相关SDB的存在与较高的BDI评分显著相关，但仅在男性中如此。快速眼动期AHI与BDI评分呈正相关，但仅在患有REM相关SDB的男性中如此。有或没有REM相关SDB的患者在ESS和SF-36评分上没有差异。
REM相关SDB患者占韩国成年OSA患者的18%。REM相关SDB与抑郁症状相关，但仅在男性中如此。快速眼动期AHI与患有REM相关SDB的男性的抑郁症状程度呈正相关。
