Kwok Y N, Verchere C B, McIntosh C H, Brown J C
Faculty of Medicine, Department of Physiology, University of British Columbia, Vancouver, Canada.
Eur J Pharmacol. 1988 Jan 5;145(1):49-54. doi: 10.1016/0014-2999(88)90347-0.
Nerves containing galanin immunoreactivity have been shown to be present in the stomach and pancreas. The present experiments were designed to test the effect of galanin on the release of gastric somatostatin-like immunoreactivity (SLI) and immunoreactive gastrin (IR-G), pancreatic SLI and immunoreactive insulin (IR-I) from the isolated perfused rat stomach and pancreas respectively. Galanin (2 X 10(-10)-5 X 10(-8) M) inhibited gastric SLI and IR-G release dose dependently. At a concentration of 10(-8) M, galanin also suppressed IR-I release stimulated by gastric inhibitory polypeptide (2 X 10(-10) M) in the presence of 8.9 X 10(-3) M glucose. Pancreatic SLI release under this condition was not altered. Thus the present study suggests that galanin might be involved in the neural regulation of gastric and pancreatic endocrine secretions.
已证实含有甘丙肽免疫反应性的神经存在于胃和胰腺中。本实验旨在分别测试甘丙肽对从离体灌注的大鼠胃和胰腺释放胃生长抑素样免疫反应性物质（SLI）、免疫反应性胃泌素（IR-G）、胰腺SLI和免疫反应性胰岛素（IR-I）的影响。甘丙肽（2×10⁻¹⁰ - 5×10⁻⁸ M）剂量依赖性地抑制胃SLI和IR-G的释放。在10⁻⁸ M的浓度下，在8.9×10⁻³ M葡萄糖存在的情况下，甘丙肽还抑制了由胃抑制性多肽（2×10⁻¹⁰ M）刺激的IR-I释放。在此条件下胰腺SLI的释放未发生改变。因此，本研究表明甘丙肽可能参与胃和胰腺内分泌分泌的神经调节。
