培养的兔主动脉平滑肌细胞分泌一种新的生长因子，即平滑肌细胞衍生生长因子，它不同于血小板衍生生长因子。

Secretion of a new growth factor, smooth muscle cell derived growth factor, distinct from platelet derived growth factor by cultured rabbit aortic smooth muscle cells.

作者信息

Morisaki N, Kanzaki T, Koshikawa T, Saito Y, Yoshida S

机构信息

Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.

出版信息

FEBS Lett. 1988 Mar 28;230(1-2):186-90. doi: 10.1016/0014-5793(88)80668-9.

DOI:10.1016/0014-5793(88)80668-9

PMID:2450784

Abstract

In attempts to determine the mechanism of proliferation of arterial smooth muscle cells (SMC) in intimal atheromatous lesions, autocrine secretion of growth factors by SMC has recently received much attention. Here we report a new growth factor named smooth muscle cell derived growth factor (SDGF). Cultured rabbit medial SMC secreted SDGF for 1 week during their incubation in serum-free media only after at least 4 passages. SDGF differed from platelet derived growth factor (PDGF) physicochemically, immunologically, and biologically. The properties of SDGF also seemed different from those of other known growth factors that stimulate the proliferation of mesenchymal cells.

摘要

为了确定动脉粥样硬化内膜病变中动脉平滑肌细胞（SMC）增殖的机制，SMC自分泌生长因子最近受到了广泛关注。在此，我们报告一种名为平滑肌细胞衍生生长因子（SDGF）的新生长因子。培养的兔中膜SMC在无血清培养基中孵育期间，仅在至少传代4次后才分泌SDGF达1周。SDGF在物理化学性质、免疫学性质和生物学性质上与血小板衍生生长因子（PDGF）不同。SDGF的特性似乎也与其他已知的刺激间充质细胞增殖的生长因子不同。