AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, United States.
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, United States.
Cytokine Growth Factor Rev. 2014 Apr;25(2):107-13. doi: 10.1016/j.cytogfr.2014.01.001. Epub 2014 Jan 10.
BLyS family members govern selection and survival of cells in the pre-immune B cell compartment, and emerging evidence suggests similar roles in antigen-experienced B cell pools. We review the features of this family, with particular emphasis on recent findings of how BLyS influences affinity maturation in germinal centers, which lie at the intersection of the pre-immune and antigen-experienced B cell compartments. We propose a model whereby tolerogenic selection at the transitional stage and affinity maturation in the germinal center employ the same BLyS driven mechanism.
B 淋巴细胞刺激因子家族成员调控初级 B 细胞池内的细胞选择和存活，新出现的证据表明它们在抗原经历的 B 细胞池内也发挥着相似的作用。我们对该家族的特点进行了综述，特别强调了最近发现的 B 淋巴细胞刺激因子如何影响生发中心内的亲和力成熟，而生发中心位于初级和抗原经历的 B 细胞池的交界处。我们提出了一个模型，其中过渡阶段的耐受选择和生发中心内的亲和力成熟都采用相同的 B 淋巴细胞刺激因子驱动机制。
