Sibley School of Mechanical and Aerospace Engineering, 220 Upson Hall, Cornell University, Ithaca, NY 14853, USA.
Sibley School of Mechanical and Aerospace Engineering, 220 Upson Hall, Cornell University, Ithaca, NY 14853, USA.
J Biomech. 2014 Mar 21;47(5):944-8. doi: 10.1016/j.jbiomech.2014.01.026. Epub 2014 Jan 20.
The age-related reduction in muscle force cannot be fully explained by the loss of muscle fiber mass or degeneration of myofibers. Our previous study showed that changes in lateral transmission of force could affect the total force transmitted to the tendon. The extracellular matrix (ECM) of skeletal muscle plays an important role in lateral transmission of force. The objective of this study was to define the effects of aging on lateral transmission of force in skeletal muscles, and explore possible underlying mechanisms. In vitro contractile tests were performed on extensor digitorum longus (EDL) muscle of young and old rats with series of tenotomy and myotomy. We concluded that lateral transmission of force was impaired in the old rats, and this deficit could be partly due to increased thickness of the ECM induced by aging.
肌肉力量随年龄的增长而下降，这不能完全用肌肉纤维质量的损失或肌纤维的退化来解释。我们之前的研究表明，力的横向传递的变化会影响传递到肌腱的总力。骨骼肌的细胞外基质 (ECM) 在力的横向传递中起着重要作用。本研究的目的是确定衰老对骨骼肌力的横向传递的影响，并探讨可能的潜在机制。我们对年轻和老年大鼠的伸趾长肌 (EDL) 进行了一系列的肌腱切断和肌切开的体外收缩试验。我们得出的结论是，力的横向传递在老年大鼠中受到损害，这种缺陷可能部分归因于衰老引起的 ECM 厚度增加。
