Vassileva Christina M, Ghazanfari Naseem, Markwell Stephen, Boley Theresa, Hazelrigg Stephen
Department of Surgery, Southern Illinois University School of Medicine, Springfield, Ill.
Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, Ill.
J Thorac Cardiovasc Surg. 2014 Oct;148(4):1393-9. doi: 10.1016/j.jtcvs.2013.12.010. Epub 2014 Jan 1.
Elderly patients are under-represented in most surgical series of mitral valve surgery. The impact of preoperative heart failure (HF) on the outcomes of this subset has not been extensively studied.
The study included 45,082 Medicare beneficiaries who underwent primary isolated mitral valve repair (MVP) (n=16,850) or replacement (MVR) (n=28,232) from 2000 to 2009. Medicare claims from the year before and the year of the index hospitalization were reviewed for documentation of HF to examine the operative mortality and long-term survival of patients with and without preoperative HF. Preoperative HF was present in 52.5% and 64.8% of patients who underwent repair and replacement, respectively. Duration of HF greater than 3 months was present in a significant proportion of patients (18.2% for MVP and 22.7% for MVR). Adjusted operative mortality was higher for patients with preoperative HF (MVP odds ratio [OR], 1.46; 95% confidence interval [CI], 1.21-1.78; MVR OR, 1.36; 95% CI, 1.23-1.51). Patients without preoperative HF had better long-term survival (MVP hazard ratio [HR], 2.23 [95% CI, 2.09-2.36]; MVR HR, 1.80 [95% CI, 1.73-1.86]). After adjustment, a preoperative HF diagnosis was still associated with 52% and 36% increased risk of death over the 10-year follow-up period for patients who underwent MVP and MVR, respectively. Preoperative HF duration greater than 3 months conferred an excess 28% higher risk of death on long-term follow-up compared with patients with HF less than 3 months.
Preoperative HF is present in a large number of elderly patients undergoing primary isolated mitral valve surgery and adversely affects their short-term and long-term survival, irrespective of procedure type (repair or replacement). The study supports the early identification of elderly patients with mitral valve disease and referral to surgery before the onset of HF.
在大多数二尖瓣手术系列研究中,老年患者的代表性不足。术前心力衰竭(HF)对这一亚组患者手术结果的影响尚未得到广泛研究。
本研究纳入了2000年至2009年间接受初次单纯二尖瓣修复术(MVP)(n = 16,850)或置换术(MVR)(n = 28,232)的45,082名医疗保险受益人。回顾了索引住院前一年和住院当年的医疗保险理赔记录,以获取HF的记录,从而检查有和没有术前HF的患者的手术死亡率和长期生存率。接受修复术和置换术的患者中,术前HF的发生率分别为52.5%和64.8%。相当一部分患者的HF持续时间超过3个月(MVP患者中为18.2%,MVR患者中为22.7%)。术前HF患者的调整后手术死亡率更高(MVP优势比[OR],1.46;95%置信区间[CI],1.21 - 1.78;MVR OR,1.36;95% CI,1.23 - 1.51)。没有术前HF的患者长期生存率更高(MVP风险比[HR],2.23 [95% CI,2.09 - 2.36];MVR HR,1.80 [95% CI,1.73 - 1.86])。调整后,术前HF诊断在接受MVP和MVR的患者10年随访期内,分别仍与死亡风险增加52%和36%相关。与HF持续时间少于3个月的患者相比,术前HF持续时间超过3个月在长期随访中死亡风险高出28%。
大量接受初次单纯二尖瓣手术的老年患者存在术前HF,且无论手术类型(修复或置换),都会对其短期和长期生存产生不利影响。该研究支持早期识别患有二尖瓣疾病的老年患者,并在HF发作前转诊进行手术。