Choudhry Samreen Z, Bhatia Neal, Ceilley Roger, Hougeir Firas, Lieberman Robert, Hamzavi Iltefat, Lim Henry W
J Drugs Dermatol. 2014 Feb;13(2):148-53.
Polypodium leucotomos extract (PLE), derived from the tropical fern of Polypodiaceae family, has properties ranging from immunomodulatory and antioxidative to photoprotective. It is these multiple mechanisms of action, in combination with a favorable side effect profile, which makes PLE a promising adjunctive treatment for several dermatologic disorders. Studies are summarized on the use and potential applications of PLE in the treatment or management of photodermatoses, vitiligo, melasma, psoriasis, atopic dermatitis, and more recently, in minimizing infections in high-performance athletes. More data, however, with larger sample sizes are needed to confirm these benefits.
白叶铁线蕨提取物（PLE）源自水龙骨科的热带蕨类植物，具有从免疫调节、抗氧化到光保护等多种特性。正是这些多种作用机制，再加上良好的副作用谱，使得PLE成为几种皮肤病的一种有前景的辅助治疗方法。本文总结了PLE在光皮肤病、白癜风、黄褐斑、银屑病、特应性皮炎治疗或管理中的应用及潜在用途，以及最近在减少高性能运动员感染方面的应用。然而，需要更多样本量更大的数据来证实这些益处。
