Guarneri Fabrizio, Bertino Lucrezia, Pioggia Giovanni, Casciaro Marco, Gangemi Sebastiano
Department of Clinical and Experimental Medicine, Dermatology, University of Messina, 98125 Messina, Italy.
Institute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), 98164 Messina, Italy.
Antioxidants (Basel). 2021 Jul 6;10(7):1087. doi: 10.3390/antiox10071087.
Oxidative stress plays an important pathogenetic role in many chronic inflammatory diseases, including those of dermatological interest. In particular, regarding psoriasis, vitiligo, and lichen planus, excess reactive oxygen species and a decline in endogenous antioxidant systems are observed. In this regard, treatments with antioxidant properties could be appropriate therapeutic options. To date, clinical trials in dermatology on these treatments are limited. We reviewed the available studies on the efficacy of antioxidant therapies in psoriasis, vitiligo, and lichen planus. The role of herbal derivatives, vitamins, and trace elements was analyzed. The antioxidant properties of conventional therapies were also evaluated. Data from the literature suggest that antioxidants might be useful, but available studies on this topic are limited, heterogeneous, not completely standardized, and on small populations. Furthermore, in most cases, antioxidants alone are unable to induce significant clinical changes, except perhaps in mild forms, and must be used in conjunction with standard drug treatments to achieve measurable results. Further studies need to be conducted, considering larger populations and using internationally validated scales, in order to compare the results and clinical efficacy.
氧化应激在许多慢性炎症性疾病中发挥着重要的致病作用，包括那些皮肤科关注的疾病。特别是在银屑病、白癜风和扁平苔藓方面，观察到活性氧物质过量以及内源性抗氧化系统下降。在这方面，具有抗氧化特性的治疗方法可能是合适的治疗选择。迄今为止，皮肤科针对这些治疗方法的临床试验有限。我们回顾了关于抗氧化疗法在银屑病、白癜风和扁平苔藓中疗效的现有研究。分析了草药衍生物、维生素和微量元素的作用。还评估了传统疗法的抗氧化特性。文献数据表明抗氧化剂可能有用，但关于该主题的现有研究有限、异质性大、未完全标准化且样本量小。此外，在大多数情况下，单独使用抗氧化剂无法引起显著的临床变化，可能轻度病例除外，并且必须与标准药物治疗联合使用才能取得可测量的结果。需要进行进一步的研究，考虑更大的样本量并使用国际认可的量表，以便比较结果和临床疗效。
