Konidari A, Auth M K H, Murphy M H, Cunningham C, Foweather L, Gobbi R, Graves L E F, Hopkins N D, Stratton G, Boddy L M
Department of Paediatric Gastroenterology, Hepatology and Nutrition, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Acta Paediatr. 2014 May;103(5):e194-8. doi: 10.1111/apa.12591. Epub 2014 Mar 13.
The aim of this study was to investigate clustered cardiometabolic risk scores in healthy 10- to 12-year-olds using anthropometric characteristics, measurements of cardiorespiratory fitness (CRF) and physical activity and blood markers of metabolic disease. We also evaluated how including markers of liver cell injury would affect the clustered cardiometabolic risk assessment model.
This cross-sectional study focused on 99 children aged 10-12 years. The main outcome included assessing participants with increased and low cardiometabolic risk factors using a clustered risk score model that incorporated markers implicated in metabolic syndrome pathogenesis. Two clustered risk scores were calculated, one incorporating markers of liver cell injury.
Children classified as 'increased risk' exhibited significantly lower CRF and higher body mass index Z-scores than their 'low-risk' peers. No significant differences in physical activity were observed. This trend remained unchanged when markers of liver injury were included in the clustered risk assessment model.
The clustered risk score model is a scientifically robust method of cardiometabolic risk assessment, which reiterates the importance of weight reduction and CRF promotion in childhood. Our study did not show a significant contribution of liver injury markers, and further research is needed to evaluate their effect on cardiometabolic risk stratification in childhood.
本研究旨在利用人体测量学特征、心肺适能（CRF）测量、身体活动以及代谢疾病的血液标志物，调查10至12岁健康儿童的聚集性心脏代谢风险评分。我们还评估了纳入肝细胞损伤标志物如何影响聚集性心脏代谢风险评估模型。
这项横断面研究聚焦于99名10至12岁的儿童。主要结果包括使用纳入了与代谢综合征发病机制相关标志物的聚集风险评分模型，评估具有升高和低心脏代谢风险因素的参与者。计算了两个聚集风险评分，其中一个纳入了肝细胞损伤标志物。
被归类为“风险增加”的儿童与“低风险”同龄人相比，CRF显著更低，体重指数Z评分更高。未观察到身体活动方面的显著差异。当在聚集风险评估模型中纳入肝损伤标志物时，这一趋势保持不变。
聚集风险评分模型是一种科学可靠的心脏代谢风险评估方法，这重申了儿童期减重和提高CRF的重要性。我们的研究未显示肝损伤标志物有显著贡献，需要进一步研究来评估它们对儿童心脏代谢风险分层的影响。
