一个RNA二级结构工作平台。
An RNA secondary structure workbench.
作者信息
Martinez H M
机构信息
Department of Biochemistry and Biophysics, University of California, San Franciso 94143.
出版信息
Nucleic Acids Res. 1988 Mar 11;16(5):1789-98. doi: 10.1093/nar/16.5.1789.
Abstract
A multiple approach to the study of RNA secondary structure is described which provides for the independent drawing of structures using base-pairing lists, for the generation of local structures in the form of hairpins, and for the generation of global structures by both Monte Carlo and dynamic programming methodologies. User-adjustable parameters provide for limiting the size of hairpin loops, bulges and inner loops, and constraints can be imposed relative to position-dependent base pairing.
摘要
本文描述了一种用于研究RNA二级结构的多重方法，该方法可通过碱基配对列表独立绘制结构，以发夹形式生成局部结构，并通过蒙特卡罗方法和动态规划方法生成全局结构。用户可调整的参数用于限制发夹环、凸起和内环的大小，并且可以针对位置依赖性碱基配对施加约束。
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本文引用的文献
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Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information.利用热力学和辅助信息对大型RNA序列进行最优计算机折叠
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Globin mRNA sequences: analysis of base pairing and evolutionary implications.珠蛋白mRNA序列：碱基配对分析及其进化意义
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