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生成核酸二级结构的非重叠展示。

Generating non-overlapping displays of nucleic acid secondary structure.

作者信息

Shapiro B A, Maizel J, Lipkin L E, Currey K, Whitney C

出版信息

Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):75-88. doi: 10.1093/nar/12.1part1.75.

DOI:10.1093/nar/12.1part1.75
PMID:6694904
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC320985/
Abstract

A new algorithm is presented which permits the display of nucleic acid secondary structure by computer. This algorithm circumvents the problem of overlapping portions of the molecule which is inherent in some other drawing programs. The results from this algorithm may also be used as input to the drawing algorithm previously reported in this journal [1] to untangle most of a drawing. The algorithm also represents the molecule in a form which makes visual comparisons for similarity quite easy since it guarantees that comparable features will reside in the same relative position in the drawings when the drawings are normalized.

摘要

本文提出了一种新算法,可通过计算机显示核酸二级结构。该算法避免了分子重叠部分的问题,而这在其他一些绘图程序中是固有的。该算法的结果也可作为输入,用于本刊之前报道的绘图算法[1],以解开大部分绘图。该算法还以一种形式表示分子,使得相似性的视觉比较非常容易,因为它保证在绘图归一化时,可比较的特征将位于绘图中的相同相对位置。

相似文献

1
Generating non-overlapping displays of nucleic acid secondary structure.生成核酸二级结构的非重叠展示。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):75-88. doi: 10.1093/nar/12.1part1.75.
2
Energy directed folding of RNA sequences.RNA序列的能量导向折叠
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3
An algorithm for the display of nucleic acid secondary structure.一种用于显示核酸二级结构的算法。
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4
An interactive technique for the display of nucleic acid secondary structure.一种用于展示核酸二级结构的交互式技术。
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5
Visualization of RNA secondary structures using highly parallel computers.利用高度并行计算机对RNA二级结构进行可视化。
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6
Steps toward computer analysis of nucleotide sequences.核苷酸序列计算机分析的步骤。
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An algorithm for the bonding-probability map of nucleic acid secondary structure.一种用于核酸二级结构结合概率图谱的算法。
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Computer programs for nucleic acids studies. Atomic coordinates of helices and their graphic display.用于核酸研究的计算机程序。螺旋结构的原子坐标及其图形显示。
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Computer method for predicting the secondary structure of single-stranded RNA.预测单链RNA二级结构的计算机方法。
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Fast algorithm for predicting the secondary structure of single-stranded RNA.预测单链RNA二级结构的快速算法
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6309-13. doi: 10.1073/pnas.77.11.6309.

引用本文的文献

1
RNA2Drawer: geometrically strict drawing of nucleic acid structures with graphical structure editing and highlighting of complementary subsequences.RNA2Drawer:具有图形结构编辑功能的核酸结构的几何精确绘制,并突出互补子序列。
RNA Biol. 2019 Dec;16(12):1667-1671. doi: 10.1080/15476286.2019.1659081. Epub 2019 Aug 26.
2
RiboSketch: versatile visualization of multi-stranded RNA and DNA secondary structure.RiboSketch:多功能可视化多链 RNA 和 DNA 二级结构。
Bioinformatics. 2018 Dec 15;34(24):4297-4299. doi: 10.1093/bioinformatics/bty468.
3
DyNAMiC Workbench: an integrated development environment for dynamic DNA nanotechnology.动态工作台:用于动态DNA纳米技术的集成开发环境。
J R Soc Interface. 2015 Oct 6;12(111):20150580. doi: 10.1098/rsif.2015.0580.
4
R2R--software to speed the depiction of aesthetic consensus RNA secondary structures.R2R--用于加速描绘美学共识 RNA 二级结构的软件。
BMC Bioinformatics. 2011 Jan 4;12:3. doi: 10.1186/1471-2105-12-3.
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RnaViz, a program for the visualisation of RNA secondary structure.RnaViz,一款用于可视化RNA二级结构的程序。
Nucleic Acids Res. 1997 Nov 15;25(22):4679-84. doi: 10.1093/nar/25.22.4679.
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RAGA: RNA sequence alignment by genetic algorithm.RAGA:基于遗传算法的RNA序列比对
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Complete nucleotide sequence of an attenuated hepatitis A virus: comparison with wild-type virus.减毒甲型肝炎病毒的完整核苷酸序列:与野生型病毒的比较。
Proc Natl Acad Sci U S A. 1987 Apr;84(8):2497-501. doi: 10.1073/pnas.84.8.2497.
8
Thermodynamic stability and statistical significance of potential stem-loop structures situated at the frameshift sites of retroviruses.逆转录病毒移码位点处潜在茎环结构的热力学稳定性和统计学意义。
Nucleic Acids Res. 1989 Aug 11;17(15):6143-52. doi: 10.1093/nar/17.15.6143.
9
The 7S RNA from tomato leaf tissue resembles a signal recognition particle RNA and exhibits a remarkable sequence complementarity to viroids.来自番茄叶片组织的7S RNA类似于信号识别颗粒RNA,并与类病毒表现出显著的序列互补性。
EMBO J. 1988 Dec 20;7(13):4063-74. doi: 10.1002/j.1460-2075.1988.tb03300.x.
10
An RNA secondary structure workbench.一个RNA二级结构工作平台。
Nucleic Acids Res. 1988 Mar 11;16(5):1789-98. doi: 10.1093/nar/16.5.1789.

本文引用的文献

1
An interactive technique for the display of nucleic acid secondary structure.一种用于展示核酸二级结构的交互式技术。
Nucleic Acids Res. 1982 Nov 11;10(21):7041-52. doi: 10.1093/nar/10.21.7041.
2
Splice junctions: association with variation in protein structure.剪接位点:与蛋白质结构变异的关联
Science. 1983 Jun 10;220(4602):1125-9. doi: 10.1126/science.6344214.
3
Computer-aided prediction of RNA secondary structures.RNA二级结构的计算机辅助预测。
Nucleic Acids Res. 1982 Jan 11;10(1):403-19. doi: 10.1093/nar/10.1.403.
4
Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information.利用热力学和辅助信息对大型RNA序列进行最优计算机折叠
Nucleic Acids Res. 1981 Jan 10;9(1):133-48. doi: 10.1093/nar/9.1.133.
5
Fast algorithm for predicting the secondary structure of single-stranded RNA.预测单链RNA二级结构的快速算法
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6309-13. doi: 10.1073/pnas.77.11.6309.
6
Method for predicting RNA secondary structure.预测RNA二级结构的方法。
Proc Natl Acad Sci U S A. 1975 Jun;72(6):2017-21. doi: 10.1073/pnas.72.6.2017.
7
The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor.小鼠β-珠蛋白基因的间隔序列在15Sβ-珠蛋白mRNA前体中被转录。
Proc Natl Acad Sci U S A. 1978 Mar;75(3):1309-13. doi: 10.1073/pnas.75.3.1309.
8
Computer method for predicting the secondary structure of single-stranded RNA.预测单链RNA二级结构的计算机方法。
Nucleic Acids Res. 1978 Sep;5(9):3365-87. doi: 10.1093/nar/5.9.3365.