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深部脑磁刺激可促进成年小鼠海马神经发生，并缓解神经精神疾病小鼠模型中与应激相关的行为。

Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders.

作者信息

Zhang Yan, Mao Rong-Rong, Chen Zhi-Fang, Tian Meng, Tong Da-Li, Gao Zheng-Run, Huang Min, Li Xiao, Xu Xiu, Zhou Wen-Hao, Li Cheng-Yu, Wang Jiang, Xu Lin, Qiu Zilong

机构信息

Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

出版信息

Mol Brain. 2014 Feb 11;7:11. doi: 10.1186/1756-6606-7-11.

DOI:10.1186/1756-6606-7-11
PMID:24512669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3928113/
Abstract

BACKGROUND

Repetitive Transcranial Magnetic Stimulation (rTMS)/ Deep-brain Magnetic Stimulation (DMS) is an effective therapy for various neuropsychiatric disorders including major depression disorder. The molecular and cellular mechanisms underlying the impacts of rTMS/DMS on the brain are not yet fully understood.

RESULTS

Here we studied the effects of deep-brain magnetic stimulation to brain on the molecular and cellular level. We examined the adult hippocampal neurogenesis and hippocampal synaptic plasticity of rodent under stress conditions with deep-brain magnetic stimulation treatment. We found that DMS promotes adult hippocampal neurogenesis significantly and facilitates the development of adult new-born neurons. Remarkably, DMS exerts anti-depression effects in the learned helplessness mouse model and rescues hippocampal long-term plasticity impaired by restraint stress in rats. Moreover, DMS alleviates the stress response in a mouse model for Rett syndrome and prolongs the life span of these animals dramatically.

CONCLUSIONS

Deep-brain magnetic stimulation greatly facilitates adult hippocampal neurogenesis and maturation, also alleviates depression and stress-related responses in animal models.

摘要

背景

重复经颅磁刺激（rTMS）/深部脑磁刺激（DMS）是治疗包括重度抑郁症在内的各种神经精神疾病的有效疗法。rTMS/DMS对大脑影响的分子和细胞机制尚未完全了解。

结果

在此，我们在分子和细胞水平上研究了深部脑磁刺激对大脑的影响。我们通过深部脑磁刺激治疗，检测了应激条件下啮齿动物的成年海马神经发生和海马突触可塑性。我们发现，DMS显著促进成年海马神经发生，并促进成年新生神经元的发育。值得注意的是，DMS在习得性无助小鼠模型中发挥抗抑郁作用，并挽救了受束缚应激损害的大鼠海马长期可塑性。此外，DMS减轻了雷特综合征小鼠模型中的应激反应，并显著延长了这些动物的寿命。

结论

深部脑磁刺激极大地促进了成年海马神经发生和成熟，还减轻了动物模型中的抑郁和应激相关反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b136/3928113/30f17b072f1d/1756-6606-7-11-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b136/3928113/68121eee3c7b/1756-6606-7-11-1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b136/3928113/68121eee3c7b/1756-6606-7-11-1.jpg
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