Uldry P A, Regli F, Ferrazzini M
Centre Hospitalier Universitaire Vaudois, Lausanne Service de Neurologie.
Schweiz Arch Neurol Psychiatr (1985). 1988;139(1):31-8.
A 50-year-old man had a primary lymphoma of the central nervous system one year after a tick bite and a radiculoneuritis secondary to Borrelia burgdorferi infection. Determination of antibodies against Borrelia burgdorferi revealed increasing IgM and IgG titers, and the autopsy showed a primary B-cell immunoblastic lymphoma of the brain without evidence of extraneural lymphoproliferative disorder. Lymphoma of the brain is a rare type of central nervous system cancer, and sporadic cases appear without predisposing features such as immunosuppression or viral infection. The controversy surrounding the histogenesis of this neoplasm is reviewed: an unknown agent or a cofactor should provoke cellular proliferation and the formation of a lymphoma.
一名50岁男性在蜱叮咬后1年发生中枢神经系统原发性淋巴瘤，并继发于伯氏疏螺旋体感染的神经根神经炎。针对伯氏疏螺旋体的抗体检测显示IgM和IgG滴度升高，尸检显示脑部原发性B细胞免疫母细胞淋巴瘤，无神经外淋巴增殖性疾病证据。脑淋巴瘤是一种罕见的中枢神经系统癌症，散发病例出现时无免疫抑制或病毒感染等易感特征。本文综述了围绕该肿瘤组织发生的争议：一种未知因素或辅助因子应引发细胞增殖并形成淋巴瘤。
