海马体体积与多发性硬化症中的认知衰退及穹窿部扩散测量指标相关。
Hippocampal volume is related to cognitive decline and fornicial diffusion measures in multiple sclerosis.
作者信息
Koenig Katherine A, Sakaie Ken E, Lowe Mark J, Lin Jian, Stone Lael, Bermel Robert A, Beall Erik B, Rao Stephen M, Trapp Bruce D, Phillips Micheal D
机构信息
Imaging Institute, Cleveland Clinic, Cleveland, OH, USA.
Imaging Institute, Cleveland Clinic, Cleveland, OH, USA.
出版信息
Magn Reson Imaging. 2014 May;32(4):354-8. doi: 10.1016/j.mri.2013.12.012. Epub 2013 Dec 30.
PURPOSE
To assess for associations between hippocampal atrophy and measures of cognitive function, hippocampal magnetization transfer ratio (MTR), and diffusion measures of the fornix, the largest efferent white matter tract from the hippocampus, in patients with multiple sclerosis (MS) and controls.
MATERIALS AND METHODS
A total of 53 patients with MS and 20 age- and sex-matched healthy controls participated in cognitive testing and scanning including high spatial-resolution diffusion imaging and a T1-MPRAGE scan. Hippocampal volume and fornicial thickness measures were calculated and compared to mean values of fornicial transverse diffusivity, mean diffusivity, longitudinal diffusivity, fractional anisotropy, mean hippocampal MTR, and scores on measures of episodic memory, processing speed, and working memory tasks.
RESULTS
In patients with MS, hippocampal volume was significantly related to fornicial diffusion measures (P<7×10(-4)) and to measures of verbal (P=0.030) and visual spatial (P=0.004) episodic memory and a measure of information processing speed (P<0.037).
DISCUSSION
These results highlight the role of the hippocampus in cognitive dysfunction in patients with MS and suggest that measures of hippocampal atrophy could be used to capture aspects of disease progression.
目的
评估多发性硬化症（MS）患者及对照组中，海马萎缩与认知功能指标、海马磁化传递率（MTR）以及海马最大传出白质束穹窿的扩散指标之间的关联。
材料与方法
共有53例MS患者及20例年龄和性别匹配的健康对照者参与了认知测试和扫描，包括高空间分辨率扩散成像和T1-MPRAGE扫描。计算海马体积和穹窿厚度指标，并与穹窿横向扩散率、平均扩散率、纵向扩散率、各向异性分数、平均海马MTR的平均值，以及情景记忆、处理速度和工作记忆任务指标的得分进行比较。
结果
在MS患者中，海马体积与穹窿扩散指标显著相关（P<7×10(-4)），与言语（P=0.030）和视觉空间（P=0.004）情景记忆指标以及信息处理速度指标（P<0.037）相关。
讨论
这些结果突出了海马在MS患者认知功能障碍中的作用，并表明海马萎缩指标可用于反映疾病进展的某些方面。
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